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  • 1995-1999  (3)
  • Nick-end labeling  (2)
  • Cochlear reperfusion injury  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Cell death caused by the acute effects of aminoglycoside and zinc in the ampullary cristae of guinea pigs (1997)
    Springer
    European archives of oto-rhino-laryngology and head & neck 254 (1997), S. 153-157 
    Details
    ISSN: 1434-4726
    Keywords: Apoptosis ; Labyrinthine vestibule ; Aminoglycoside toxicity ; Zinc toxicity ; Nick-end labeling
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We reported that apoptosis occurred in the guinea pig vestibular hair cells after chronic aminoglycoside treatments. In the present study, we used in situ nick-end labeling to determine whether apoptosis was also induced by the acute effects of aminoglycosides in guinea pig ampullar cristae. In addition, we evaluated the effect of zinc supplements upon these ototoxic treatments. After a local application of streptomycin directly to the round window, we found labeled bodies in the vestibular hair cells. The zinc supplement increased the number of labeled bodies resulting in severe hair cell loss. These findings indicate that the acute effects of aminoglycosides also induce apoptosis of the vestibular hair cells, and that zinc enhances aminoglycoside ototoxicity. Consequently, we propose that an interaction with ion channels may play a key mechanism in the processes of apoptosis affecting the vestibular hair cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02471281
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Appearance of free radicals in the guinea pig inner ear after noise-induced acoustic trauma (1995)
    Springer
    European archives of oto-rhino-laryngology and head & neck 252 (1995), S. 504-508 
    Details
    ISSN: 1434-4726
    Keywords: Noise trauma ; Superoxide anion radicals ; Strial blood flow ; Cochlear reperfusion injury
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The emergence of superoxide anion radicals (O2-) in the guinea pig inner ear following acoustic trauma was investigated by histochemical methods. Five minutes after exposure to sound at 120–125 dB SPL for 3 h, an O2- reaction product was detected in the cochlea along the luminal membrane of the marginal cells of the stria vascularis. This reaction product could not be found at 30 min, but reappeared at 2 h. The first appearance of O2- is not explainable by our studies, but the second appearance may be related to recirculation of strial blood flow after blood flow stasis. The present observations raise the possibility that free radicals are produced in the inner ear after acoustic trauma and lead to inner ear damage.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02114761
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Apoptosis of guinea pig cochlear hair cells following chronic aminoglycoside treatment (1998)
    Springer
    European archives of oto-rhino-laryngology and head & neck 255 (1998), S. 127-131 
    Details
    ISSN: 1434-4726
    Keywords: Key words Cochlea ; Aminoglycoside toxicity ; Hair cell apoptosis ; Nick-end labeling
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Although aminoglycosides have been investigated for their cochleotoxicity, it has still not been determined whether apoptosis or necrosis results in cochlear hair cell death following aminoglycoside treatment. To study possible mechanisms of cell death, we used in situ DNA break-labeling to examine guinea pig cochleae affected by kanamycin ototoxicity. Chronic kanamycin treatment induced DNA fragmentation that was detectable in both outer and inner hair cells, suggesting the occurrence of apoptosis. These findings suggest that apoptosis achieves deletion of affected hair cells without disrupting tissue architecture in the organ of Corti.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004050050027
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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