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  • 1
    Electronic Resource
    Electronic Resource
    Hyperventilation zur Vermeidung von Störungen der exkretorischen Leberfunktion im Initialstadium der Nitrostigmin-(E 605 forte®-) Vergiftung an Ratten (1972)
    Springer
    Archives of toxicology 28 (1972), S. 24-38 
    Details
    ISSN: 1432-0738
    Keywords: Organophosphate Poisoning ; Hepatic Excretory Function ; Nitrostigmine ; Bilirubin ; Hypoxemia ; Acidosis ; Organophosphatvergiftung ; Exkretorische Leberfunktion ; Nitrostigmin ; Bilirubin ; Hypoxämie ; Acidose
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wurde der Einfluß von Hypoxämie und Acidose auf den Gallenfluß, die hepatische Bilirubinelimination sowie die Konzentration von „direktem” und „indirektem” Bilirubin im Plasma Nitrostigmin-(E 605 forte®) vergifteter Ratten untersucht. Die Kombination von Hypoxämie und Acidose führt bei Nitrostigmin-vergifteten Batten zu einer signifikanten Abnahme des Gallenflusses und der hepatischen Bilirubinclearance. Die Nitrostigminvergiftung (4 μl/kg KG E 605 forte®) beeinträchtigt die exkretorische Leberfunktion nicht, wenn durch künstliche Hyperventilation (geringfügiger Anstieg des arteriellen pH-Wertes) physiologische pO2-Werte im arteriellen Blut aufrecht erhalten werden. Konsequenzen für die Behandlung von Vergiftungen mit Nitrostigmin in der Humanmedizin werden diskutiert.
    Notes: Abstract The influence of hypoxemia and respiratory acidosis on bile flow, hepatic elimination of bilirubin and the concentration of conjugated and unconjugated plasma bilirubin was studied in nitrostigmine (E 605 forte®) poisoned rats. The combination of hypoxemia and respiratory acidosis in rats poisoned with nitrostigmine results in a significant decrease in bile flow and hepatic clearance of bilirubin. Nitrostigmine poisoning (4 μl/kg b.w. E 605 forte®) does not adversely affect hepatic excretory function if arterial pO2 is maintained within the normal range by artificial hyperventilation (slight rise in arterial pH). The consequences of these studies for the treatment of human nitrostigmine intoxication are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00349625
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  • 2
    Electronic Resource
    Electronic Resource
    Determination of acetylcholine, nitrostigmine and acetylcholinesterase activity in four patients with severe nitrostigmine (E 605 forte®) intoxication (1974)
    Springer
    Archives of toxicology 32 (1974), S. 97-108 
    Details
    ISSN: 1432-0738
    Keywords: Organophosphate Intoxication ; Nitrostigmine ; Acetylcholine (ACh) ; Acetylcholinesterase (AChE) Activity ; Organophosphatvergiftung ; Nitrostigmin ; Acetylcholin (ACh) ; Acetylcholinesterase (AChE)-Aktivität
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 4 Patienten mit schwerer Nitrostigminvergiftung wurden die Konzentrationen von Acetylcholin und Nitrostigmin sowie die Aktivität der Acetylcholinesterase bestimmt. In der akuten Phase der Vergiftung wurden Acetylcholinspiegel bis zu 36 und 55 ng/ml Plasma bzw. Liquor cerebrospinalis gemessen. Zum gleichen Zeitpunkt konnte keine Acetylcholinesteraseaktivität im Plasma und Erythrocyten festgestellt werden. Die Aktivität der Acetylcholinesterase kehrte am Ende der 2. Woche wieder. Im Plasma waren Nitrostigminspiegel zwischen 409 und 86 ng/ml während der ersten 3 Tage meßbar. Nitrostigmin konnte im Plasma bis zum Ende der 3. Woche in einer Konzentration von etwa 1 ng/ml nachgewiesen werden. Als Ursache dafür werden Umverteilung aus dem Fettgewebe und Nachresorption angenommen. Die Befunde werden in Relation zum klinischen Bild besprochen.
    Notes: Abstract Concentrations of acetylcholine and nitrostigmine as well as acetylcholinesterase activity were determined in 4 patients with severe nitrostigmine intoxication. In the acute phase of the intoxication, acetylcholine levels up to 36 and 55 ng/ml were found in blood plasma and cerebrospinal fluid, respectively. At the same time no activity of acetylcholinesterase in plasma and erythrocytes was detected. Acetylcholinesterase activity gradually recovered at the end of the second week. In the first 3 days after the ingestion plasma nitrostigmine concentrations ranged from 409 to 86 ng/ml. At the end of the third week nitrostigmine was still found in a concentration of about 1 ng/ml plasma. Redistribution from fatty tissue and slow gastro-intestinal absorption may be responsible for the persistence of nitrostigmine in the blood. The findings are discussed in relation to the clinical course.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00316230
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  • 3
    Electronic Resource
    Electronic Resource
    Probable progress in the therapy of organophosphate poisoning (1976)
    Springer
    Archives of toxicology 35 (1976), S. 221-227 
    Details
    ISSN: 1432-0738
    Keywords: Anticholinesterase agents ; Clearance ; Demeton-S-methyl sulfoxide ; Dimethoate ; Hemodialysis ; Hemoperfusion ; Intoxication ; Nitrostigmine ; Organophosphate ; Therapy ; Anticholinesterasen ; Clearance ; Demeton-S-methylsulfoxid ; Dimethoat ; Hämodialyse ; Hämoperfusion ; Intoxikation ; Nitrostigmin ; Organophosphate ; Therapie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wurde untersucht, ob extracorporale Hämodialyse oder Hämoperfusion mit beschichteter Aktivkohle bei Vergiftungen mit Nitrostigmin, Demeton-S-methylsulfoxid oder Dimethoat zur Elimination der Organophosphate eingesetzt werden können. Nitrostigmin war nicht hämodialysabel. Die beiden anderen Organophosphate dagegen ließen sich gut durch Hämodialyse aus dem Blut eliminieren. Bei einem Blutfluß von 100 ml/min betrug die Clearance für Demeton-S-methylsulfoxid 52,98 ml/min und für Dimethoat 59,07 ml/min. Die Clearancewerte durch Hämoperfusion mit beschichteter Aktivkohle waren unter gleichen Versuchsbedingungen höher. Sie betrugen für Demeton-S-methylsulfoxid 83,70 ml/min und für Dimethoat 87,84 ml/min. Auch Nitrostigmin konnte durch Hämoperfusion aus dem Blut entfernt werden; die Clearance betrug 59,20 ml/min. Bei einem Patienten mit Nitrostigmin-Intoxikation in suicidaler Absicht ließen sich die o. g. Ergebnisse der in vitro-Hämoperfusion bestätigen.
    Notes: Abstract Whether or not extracorporeal hemodialysis or hemoperfusion with coated activated charcoal might be used in eliminating organophosphates following poisoning with nitrostigmine, demeton-S-methyl sulfoxide, or dimethoate was here examined. Nitrostigmine could not be hemodialysed. The other two organophosphates, on the other hand could be well eliminated from the blood by hemodialysis. The clearance rates for demeton-S-methyl sulfoxide and dimethoate were 52.98 ml/min and 59.07 ml/min respectively, at a blood flow rate of 100 ml/min. The clearance values for hemoperfusion with coated activated charcoal were higher under the same trial conditions, the values being 83.70 ml/min for demeton-S-methyl sulfoxide and 87.84 ml/min for dimethoate. Nitrostigmine, too, could be eliminated from the blood by hemoperfusion, its clearance being 59.20 ml/min. These results from in vitro hemoperfusion were verified on a patient admitted with nitrostigmine intoxication following attempted suicide.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00293570
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  • 4
    Electronic Resource
    Electronic Resource
    Therapeutic properties of haemodialysis and blood exchange transfusion in organophosphate poisoning (1976)
    Springer
    Intensive care medicine 2 (1976), S. 13-18 
    Details
    ISSN: 1432-1238
    Keywords: Anticholinesterase agents ; Blood exchange transfusion ; Demeton-S-methyl sulfoxide ; Dimethoate ; Haemodialysis ; Nitrostigmine ; Organophosphates ; Parathion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Human blood was contaminated with nitrostigmine, dimethoate and demeton-S-methyl sulfoxide. It was then dialysed, concentrations of organophosphates were determined and dialysance values calculated. The influence of blood exchange transfusion on poison elimination as well as on the cholinesterase activity of blood, brain and muscle was studied in rats poisoned with nitrostigmine. Haemodialysis was found to be quite an effective method for eliminating demeton-S-methyl sulfoxide and dimethoate, dialysance values of 52.98 ml/min and 59.07 ml/min being found for demeton-S-methyl sulfoxide and dimethoate respectively. Nitrostigmine could not be removed by haemodialysis. These findings suggest that haemodialysis could be of therapeutic value in the treatment of severe demeton-S-methyl sulfoxide and dimethoate poisoning in man. By blood exchange transfusion only 0.06% of the injected dose of nitrostigmine could be removed from the body of poisoned rats. Acetylcholinesterase activity increased only briefly in the period of blood exchange transfusion and decreased gradually afterwards. The enzymatic activity of brain and muscle was unaffected. Therefore, blood exchange transfusion has, if any at all, only poor therapeutic properties in nitrostigmine intoxication.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00571891
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    Paper (German National Licenses)
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