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  • 1970-1974  (2)
  • Nucleic acids  (1)
  • Prostatic carcinoma  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Studies on the nucleic acid metabolism of renal tumour cells in vitro (1974)
    Springer
    Urological research 2 (1974), S. 39-41 
    Details
    ISSN: 1434-0879
    Keywords: Nucleic acids ; deoxyribonucleic acid (DNA) ; ribonucleic acid (RNA) ; incorporation rate ; renal tumour ; biological activity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Renal tumours, obtained after nephrectomy, were subjected to in vitro study of the incorporation rate of C 14-8-adenine into nucleic acid bases.-In 10 examples of renal cell carcinoma, the incorporation rate into adenine and guanine were 2.01x10-2 (cpm/umole base) and 1.83x10-2 for DNA, and 3.00x10-2 and 2.83x10-2 for RNA. The incorporation rate in renal pelvic tumour was rather higher than that in renal cell carcinoma. It was demonstrated that the incorporation rate in Wilms tumour was highest.-These incorporation rates provide an index of the biological activity of the tumour cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00257947
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Human prostatic carcinoma in cell culture: Preliminary report on the development and characterization of an epithelial cell line (EB 33) (1974)
    Springer
    Urological research 2 (1974), S. 111-121 
    Details
    ISSN: 1434-0879
    Keywords: Prostatic carcinoma ; permanent cell line ; heterotransplantation ; chromosome analysis ; electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The permanent epithelial cell-line EB 33 was developed from a human prostatic carcinoma. First attempts were made to characterize this strain by functional, morphological and kinetic parameters. The doubling time was found to be quite slow and to remain constant at 50.0 h during the exponential phase of growth over many passages. High acid phosphatase activity in the cytoplasma was found by histochemical means in comparison to HeLa cells. Electron microscopic studies suggested the epithelial origin of the cell-line. The karyotype was near triploid. Successful heterotransplantation into “nude mice” was achieved reproducibly. Histological examination of the heterotransplants revealed solid epithelial tumors with a rapid rate of growth. The findings reported suggest the prostatic epithelial origin of the cell-line EB 33. Their origin from the carcinomatous part of the explanted tissue remains still unproven. Future aspects for the development of an experimental model for human prostatic carcinoma are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00254727
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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