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  • 1
    Electronic Resource
    Electronic Resource
    Albumin Nanospheres as Carriers for Passive Drug Targeting: An Optimized Manufacturing Technique (1996)
    Springer
    Pharmaceutical research 13 (1996), S. 32-37 
    Details
    ISSN: 1573-904X
    Keywords: albumin ; nanospheres ; manufacturing ; glutaraldehyde ; cross-linking ; central composite design
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Purpose. The purpose of this study was to develop a new method to produce albumin particles in the sub-200-nanometer range with a narrow size distribution and in a controlled and reproducible manner. Methods. A new emulsion crosslinking method was developed using ultrasound and static mixing as homogenization steps and a central composite design was used to evaluate the influence of different process parameters on particle size, polydispersity and yield. Results. Response surface analysis allowed the location of the most important factors. Of all the factors investigated, only the albumin concentration and the aqueous phase volume showed a significant influence on response parameters. Albumin nanospheres with sizes below 200 nm in diameter and very narrow size distributions were obtained in high yields (〉80%). Conclusions. This study describes a new preparation method for albumin nanoparticles which are suitable for future drug targeting studies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1016064930502
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  • 2
    Electronic Resource
    Electronic Resource
    Synthese von Pseudouridin C (1978)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 1978 (1978), S. 427-430 
    Details
    ISSN: 0075-4617
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Synthesis of Pseudouridine CPseudouridine C [5-(β-D-ribofuranosyl)uracyl, 6b] has been prepared in an overall yield of 9% (based on 4-bromouracil) by a seven-step synthesis starting from D-ribose (as derivative 3) and 5-bromouracil. By addition, pseudouridines AF, SS (5a, b), and B (6a) are also obtained in a joint total yield of about 30%.
    Notes: Ausgehend von D-Ribose (als Derivat 3) und 5-Bromuracil wird über sieben Stufen PseudouridinC[5-(β-D-Ribofuranosyl)uracil, 6b] in einer Gesamtausbeute von 9% (bezogen auf 5-Bromuracil) dargestellt. Die Pseudouridine AF, AS (5a, b) und B (6a) werden daneben in einer Ausbeute von zusammen rund 30% erhalten.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.197819780308
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    Paper (German National Licenses)
    Fulltext
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