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  • Methylthio compounds  (1)
  • PACS. 36.40.Wa Charged clusters – 34.50.Bw Energy loss and stopping power  (1)
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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    International archives of occupational and environmental health 46 (1980), S. 99-109 
    ISSN: 1432-1246
    Keywords: Methyl chloride ; Glutathione conjugation ; Thioethers ; Methylthio compounds ; Mercapturic acid ; S-methylcysteine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Methyl chloride is used as a methylating agent and as a blowing agent in industrial processes. Alkylating agents and other electrophilic compounds are often detoxified in the organism through conjugation with glutathione. Glutathione conjugates are generally excreted as mercapturic acids, cysteine conjugates, or other thioethers in urine. Urine samples obtained from persons occupationally exposed to methyl chloride were examined for the presence of elevated thioether levels using a previously published non-selective procedure. No significant increases were detectable. A new assay procedure was developed for the detection of methylthio compounds in urine. The method is based on alkaline hydrolysis of urine samples and subsequent gas chromatographic determination of methyl mercaptan in the headspace of acidified hydrolysates. By application of this method a greatly increased excretion of a methylthio compound in the urine of CH3Cl-exposed workers was shown. The compound was identified as S-methylcysteine. A study of the urinary S-methylcysteine excretion in a group of workers during a seven-day shift revealed that two of six workers hardly excreted any S-methylcysteine after exposure to methyl chloride.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1434-6079
    Keywords: PACS. 36.40.Wa Charged clusters – 34.50.Bw Energy loss and stopping power
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract: In an experimental study, the multi-ionisation of metallic clusters (Nan) has been analysed in collisions with light ions in low charge states (H+, He+, He2+, O3+) at collision velocities below 1 a.u. Cluster ions are produced in charge states up to 5+. The average charge of the nano-particles is found to increase linearly with the variation of projectile velocity and the square of the effective projectile charge, well in agreement with the electronic stopping power of the bulk material. A fraction of 50% to 30% of the total projectile energy loss (decreasing with velocity) is transferred into vibrational modes in good agreement with recent theoretical predictions.
    Type of Medium: Electronic Resource
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