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  • 1
    Electronic Resource
    Electronic Resource
    Hypertrophy of the olivary nucleus (1986)
    Springer
    Acta neuropathologica 69 (1986), S. 132-138 
    Details
    ISSN: 1432-0533
    Keywords: Olivary hypertrophy ; Neurofilaments ; Paired helical filaments ; Straight tubules ; Progressive supranuclear palsy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The fine structure of the hypertrophic olive is reported in a case of progressive supranuclear palsy, the cause of which would be attributed to extensive symmetrical lesions in the dentate nuclei of the cerebellum and central tegmental tracts of the pons. Ultrastructurally, the enlarged neurons and their processes showed massive aggregations of neurofilaments, large accumulations of concentric laminated bodies, and occasional abnormal neurofibers (paired helical filaments and straight tubules). Their implications are briefly discussed in relation to olivary hypertrophy. Eosinophilic globules were seen in a neuron. Glomeruloid bodies were not seen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687049
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Alzheimer's neurofibrillary tangles and paired helical filaments in the pheochromocytoma cells of the adrenal medulla —Electron microscopic and immunoelectron microscopic observations (1990)
    Springer
    Acta neuropathologica 81 (1990), S. 213-216 
    Details
    ISSN: 1432-0533
    Keywords: Alzheimer's neurofibrillary tangles ; Paired helical filaments ; Adrenal pheochromocytoma ; Antitau antibody ; Immunoelectron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Alzheimer's neurofibrillary tangles (NFT) and paired helical filaments (PHF) were found in the pheochromocytoma cells of the adrenal gland removed from a 54-year-old female. By electron microscopy they were identical to those found in the brains affected by dementia of Alzheimer type. In the tumor cells, most of the PHF were found dispersed loosely in the cytoplasm, while typical NFT were infrequent. By immunoelectron microscopy using peroxidase-antiperoxidase method, both NFT and dispersed PHF were stained positively with a polyclonal antiserum to human tau protein. This is the first observation of NFT and PHF in paraneuronal tumor cells. The patient has no obvious Alzheimer's disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00334510
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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