ISSN:
1432-1440
Keywords:
Intrahepatic abscesses
;
Peritonitis
;
Bacteroides melaninogenicus
;
Fusobacterium necrophorum
;
Histopathology of mixed anaerobic infections
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary This study characterized acute peritonitis and chronic abscess formation resulting from experimental mixed anaerobic infection withBacteroides melaninogenicus andFusobacterium necrophorum. At intervals after infection liver and spleen samples were obtained, fixed, and processed for histological examination. An acute to chronic infection progressed in mice infected with this mixture of anaerobic bacteria, whereas, no infection resulted when either organism was injected alone. Acute inflammatory cell infiltrates were noted in tissue samples at 12 h postinfection. Small, discrete areas of liver cell necrosis with neutrophilic infiltrates were observed as early as 24 h. By 48 h after infection the liver parenchyma was infiltrated with both acute and chronic inflammatory cells, with moderate to severe hepatocyte degeneration recognized at 72 h. Large intrahepatic abscesses were present in the subphrenic (upper lobe) area 2 to 6 weeks after experimental infection.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01716558
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