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  • 1
    Electronic Resource
    Electronic Resource
    Über einen im Rhesus-Blutgruppensystem wirksamen Phenolwasserextrakt aus menschlichen Erythrozyten (1967)
    Springer
    Annals of hematology 14 (1967), S. 284-286 
    Details
    ISSN: 1432-0584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary A phenol water extract of ORh-positive erythrocytes prepared at 66–68°C inhinits the hemagglutination of ORh-positive erythrocytes by incomplete human Rh-antibodies. The active component of this extract is thermostable, hardly soluble in water, but casily soluble in diluted hydrochloric acid. It is not dialysable and not electrodialysable. Periodate counteracts the inhibitory action of the hardly soluble component of the extract. Acid hydrolysis, however, produces no loss of activity.
    Notes: Zusammenfassung Ein bei 66–68° hergestellter Phenolwasserextrakt aus ORh-positiven Erythrozyten hemmt die Hämagglutination ORh-positiver Erythrozyten durch inkomplette menschliche Rh-Antikörper. Die wirksame Komponente dieses Extraktes ist thermostabil, schwerlöslich in Wasser, aber leichtlöslich in verdünnter Salzsäure; sie ist nicht dialysierbar und nicht elektrodialysierbar. Durch Perjodar-Einwirkung geht die Hemmwirkung des schwerlöslichen Anteils des Extraktes verloren. Saure Hydrolyse bewirkt dagegen keinen Aktivitätsverlust.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01632158
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  • 2
    Electronic Resource
    Electronic Resource
    Zur Frage der immunologischen Umstimmung und der Schutzwirkung von Rekonvaleszenten-Serum nach Verbrennungen (1962)
    Springer
    Journal of molecular medicine 40 (1962), S. 853-854 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01492718
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  • 3
    Electronic Resource
    Electronic Resource
    Die Bedeutung von Bakterien für die Toxicität verbrannter Haut (1965)
    Springer
    Journal of molecular medicine 43 (1965), S. 748-750 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary According to the results of our experiments the mortality after injection of extracts of burned skin is due to their bacterial contamination. Mice inoculated with extracts of burned skin from germfree rats survive, whereas extracts of burned skin from conventional rats induce a high mortality rate.
    Notes: Schlußfolgerung Die in den Versuchen festgestellte Sterblichkeit nach Injektion von Extrakten aus verbrannter Haut ist auf deren bakterielle Kontaminierung zurückzuführen. Wird die Verbrennung bei keimfreien Ratten gesetzt, verbrannte Haut zu verschiedenen Zeitpunkten nach der Schädigung steril entnommen, ein keimfreier Extrakt hergestellt und pathogenfreien Mäusen injiziert, so tritt keine Sterblichkeit auf. Das Problem der Toxicität verbrannter Haut kann deshalb nur unter sorgfältiger Berücksichtigung bakterieller Faktoren weiterverfolgt werden.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01707077
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  • 4
    Electronic Resource
    Electronic Resource
    Zur Hemmung der Endotoxinwirkung an der Mikrozirkulation durch ein Glucofuranosid-Derivat (1967)
    Springer
    Journal of molecular medicine 45 (1967), S. 955-956 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Endotoxin from gram-negative bacteria causes severe alterations in the microcirculation. After degranulation of tissue mast-cells the bloodflow begins to slow down, the plasticity of circulating red and white cells is changed, adherence of the granulocytes to the wall occurs. Increased volume of endothelial cells and pericytes is followed by narrowing of the vascular lumen and enhanced permeability and microbleeding. Aggregates of thrombocytes and microthrombi are formed, prestasis and stasis is developed. After pretreatment of the experimental animals with a Glucofuranosid-derivate the microcirculation is protected against the described damage.
    Notes: Zusammenfassung Endotoxin aus gramnegativen Keimen führt zu schweren Störungen an der terminalen Strombahn. Nach Degranulierung der Gewebsmastzellen kommt es zu Strombahnverlangsamung, Plastizitätsabnahme der roten und weißen Blutkörperchen, Wandhaftung der Granulocyten. Schwellung der Endothelzellen und Pericyten geht einher mit Permeabilitätsveränderungen; Plasma und Erythrocyten treten aus. Es entstehen Thrombocytenaggregate und Mikrothromben, über zunehmende Blutflußverlangsamung entwikkelt sich Prästase und Stase. Durch Vorbehandlung der Versuchstiere mit einem Glucofuranosid-Derivat bleiben die beschriebenen Störungen aus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01726941
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  • 5
    Electronic Resource
    Electronic Resource
    Histopathology of mixed anaerobic intraabdominal infection in mice (1982)
    Springer
    Journal of molecular medicine 60 (1982), S. 702-704 
    Details
    ISSN: 1432-1440
    Keywords: Intrahepatic abscesses ; Peritonitis ; Bacteroides melaninogenicus ; Fusobacterium necrophorum ; Histopathology of mixed anaerobic infections
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary This study characterized acute peritonitis and chronic abscess formation resulting from experimental mixed anaerobic infection withBacteroides melaninogenicus andFusobacterium necrophorum. At intervals after infection liver and spleen samples were obtained, fixed, and processed for histological examination. An acute to chronic infection progressed in mice infected with this mixture of anaerobic bacteria, whereas, no infection resulted when either organism was injected alone. Acute inflammatory cell infiltrates were noted in tissue samples at 12 h postinfection. Small, discrete areas of liver cell necrosis with neutrophilic infiltrates were observed as early as 24 h. By 48 h after infection the liver parenchyma was infiltrated with both acute and chronic inflammatory cells, with moderate to severe hepatocyte degeneration recognized at 72 h. Large intrahepatic abscesses were present in the subphrenic (upper lobe) area 2 to 6 weeks after experimental infection.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01716558
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  • 6
    Electronic Resource
    Electronic Resource
    Histaminverstärkende Wirkung von Endotoxinen aus verschiedenen gramnegativen Keimen (1965)
    Springer
    Journal of molecular medicine 43 (1965), S. 1012-1014 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Endotoxins of gramnegative bacteria (E. coli, B. abortus, B. melitensis and H. influenzae) increase the histamine effect on the smooth uterine muscle up to 900% in 109 of 125 cases. The effect can also be observed on the blood vessels of the rabbit ear. This mechanism might play a role in all phenonema in which endotoxin and histamin is involved, for example in septic and traumatic shock and the Shwartzman reaction.
    Notes: Zusammenfassung Endotoxine aus gramnegativen Keimen — geprüft wurde E. coli, B. abortus, B. melitensis und H. influenzae — steigern Histamin in seiner Wirkung an 109 von 125 Uterushörnern bis zu 900%. Diese histaminverstärkende Wirkung der Endotoxine ist auch an der glatten Muskulatur der Kaninchenohrgefäße nachweisbar. Die Bedeutung dieses Mechanismus für die Pathogenese septischer Krankheitsprozesse liegt auf der Hand.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01747867
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  • 7
    Electronic Resource
    Electronic Resource
    Erste Beobachtungen mit dem Rasterelektronenmikroskop in der Frühphase der Endotoxinwirkung an der terminalen Strombahn (1969)
    Springer
    Journal of molecular medicine 47 (1969), S. 1166-1170 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary By Scanning Electron Microscopy the terminal bloodflow of the hamster cheek pouch and the rabbit mesenterium was studied for 50 minutes after intravenous injection of endotoxin. The resulting findings were compared with vitalmicroscopic observed changes of the microcirculation. Caused by endotoxin the surface of the cells especially of the erythrocytes undergo considerable deformations as already known from the vitalmicroscopic studies. Aggregation of platelets, which are formed in the terminal blood flow after application of endotoxin were recognized as irreversible aggregates (thrombus) of platelets by means of the Stereoscan-technique. Fibrin and platelets were identified in aggregates of erythrocytes which often appear disseminate in many of the small vessels adhaering to the wall.
    Notes: Zusammenfassung Mittels REM wurde an Hamsterbackentasche und Kaninchenmesenterium die terminale Strombahn 50 min nach intravenöser Injektion von Endotoxin untersucht. Die hierbei erhobenen Befunde wurden zu den vitalmikroskopisch erkennbaren Veränderungen an der Mikrozirkulation in Parallele gesetzt. Wie schon aus vitalmikroskopischen Untersuchungen bekannt, treten erhebliche Deformierungen der Zelloberfläche besonders bei den Erythrocyten endotoxinbedingt auf. Aggregation von Thrombocyten, die in der terminalen Strombahn nach Endotoxingabe entstehen, konnten mittels der Stereoscantechnik als irreversible Thrombocytenthromben erkannt werden. In Aggregaten von Erythrocyten, die sich vielerorts in den kleinen Gefäßen häufig wandadhärent entwickeln, konnte im Rasterelektronenmikroskop Fibrin mit Thrombocyten nachgewiesen werden.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01483746
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  • 8
    Electronic Resource
    Electronic Resource
    THE HISTAMINE-SENSITIZING EFFECT OF ENDOTOXINS (1966)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 133 (1966), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1966.tb52400.x
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  • 9
    Electronic Resource
    Electronic Resource
    Occurrence of an Rh -like Antigen in Red Cells of the Sheep (1961)
    [s.l.] : Nature Publishing Group
    Nature 191 (1961), S. 193-193 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Apart from the Rh-antibody obtained by immunization of guinea pigs with rhesus erythrocytes, there are antibodies formed in women eventually immunized when bearing a foetus possessing Rh-erythrocytes or possibly formed in human males and females following transfusion of blood incompatible with Rh. ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/191193a0
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  • 10
    Electronic Resource
    Electronic Resource
    The ''Free Lipids'' of Brucella abortus Bang - I. Investigation of the phosphatides
    Amsterdam : Elsevier
    BBA - Specialised Section On Lipids and Related Subjects 84 (1964), S. 376-390 
    Details
    ISSN: 0926-6542
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0926-6542(64)90002-2
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