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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 352 (1995), S. 679-684 
    ISSN: 1432-1912
    Keywords: Key words Calmodulin antagonistsr ; Phosphoinositide turnover ; Phospholipase C ; C6-glioma cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  To investigate the role of calmodulin (CaM)-dependent pathways in agonist-induced phosphoinositide (PI) turnover, the influence of several CaM antagonists on PI-phospholipase C (PLC) activation in intact and permeabilized C6 glioma cells was examined. The extent of PI turnover was assessed by measuring the accumulation of inositol phosphates (IPs) in the presence of LiCl in C6 glioma cells prelabelled with myo-[3H]inositol. Trifluoperazine, N-(6-aminohexyl)-5-chloro-1-naphthalenesulphonamide (W-7), fendiline and calmidazolium themselves had no effect on basal IP formation, but concentration-dependently (1–30 μM) potentiated ATP-, NaF- and A23187-stimulated IP formation. The maximal response to ATP (1 mM) was increased by up to 50%, while the concentration for half-maximal effect (EC50, 60 μM) was unaffected by trifluoperazine. In digitonin-permeabilized C6 glioma cells, the concentration-dependent increase of PI-PLC activation elicited by free Ca2+ was potentiated by the GTP analogue, guanosine 5′-[γ-thio]triphosphate (GTPγS), with an EC50 of 6 μM. Trifluoperazine (1–30 μM) enhanced the Ca2+-stimulated IP formation concentration dependently and this potentiation was counteracted by the addition of CaM. In the combined presence of each CaM antagonist studied and GTPγS, an additive increase in IP formation was observed. The results indicate that CaM antagonists enhance stimulus-induced IP formation in C6 glioma cells primarily by increasing the Ca2+-dependent activation of PI-PLC.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 354 (1996), S. 53-58 
    ISSN: 1432-1912
    Keywords: Key words SK&F 96365 ; M3 muscarinic receptor ; Phosphoinositide turnover ; SH-SY5Y neuroblastoma ; Cerebellar granule cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  SK&F 96365, a receptor-mediated Ca2+ entry inhibitor, has been reported to inhibit Ca2+ res- ponses to various agonists without affecting internal Ca2+ release and phosphoinositide turnover. Since muscarinic acetylcholine receptor-mediated phospho- inositide turnover shows a marked dependence on factors affecting cytosolic Ca2+ concentration, the effects of SK&F 96365 on the coupling of muscarinic receptors to the phosphoinositide hydrolysis were examined in human neuroblastoma SH-SY5Y and rat cerebellar granule cells. SK&F 96365 concentration-dependently (3–30 μM) inhibited the inositol phosphate formation elicited by carbachol in both cellular systems. Moreover, SK&F 96365 inhibited the carbachol-induced inositol phosphate formation in the absence of extracellular Ca2+, and similar extent of inhibition was achieved in the presence or absence of extracellular Ca2+. In ligand binding studies, we found that the binding affinities for [3H] N-methyl scopolamine in both cells were attenuated by SK&F 96365 (3–30 μM), while Bmax values for the ligand were not changed. The competition curves of SK&F 96365 showed a Ki value of 28.4 uM in SH-SY5Y cells. The results indicated that the decrease of carbachol-stimulated phosphoinositide hydrolysis by SK&F 96365 is due to the competitive inhibition of agonist binding to the M3 muscarinic receptors.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 20 (1974), S. 306-310 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A thermal continuous parametric pump for separating multicomponent mixtures was experimentally investigated using the model system tolueneaniline-n-heptane on silica gel adsorbent. A simple method for predicting separations is presented and is found to be in good agreement with the experimental results. The method, based on an equilibrium theory, invokes the assumption that a multicomponent mixture contains a series of pseudo binary systems. Each binary system consists of one of the solutes as one component and the common inert solvent as the other component.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 41 (1995), S. 2314-2317 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Brookfield, Conn. : Wiley-Blackwell
    Journal of Vinyl and Additive Technology 2 (1980), S. 74-76 
    ISSN: 0193-7197
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Process Engineering, Biotechnology, Nutrition Technology
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Acta Polymerica 45 (1994), S. 41-46 
    ISSN: 0323-7648
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Changes in the rheological properties of chitosan solutions with pH, ionic strength, and type of anion were studied. Between pH 2.0 and 5.0, apparent viscosities increased with the decrease of pH in chitosan-organic acid solutions, while in chitosan-HCl solutions they behaved oppositely. In chitosan-NaOH solutions, they decreased with the increase of pH between pH 5.0 and 6.0, then increased as pH further increased to pH 6.0-6.4. The difference may be due to different interactions of counterions with macroions and also the third electroviscous effect. Relative viscosity increased with a decrease in chitosan concentrations at concentrations below 1.5 × 10-3 M. Intrinsic viscosities changed with media pH and ionic strength.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 42 (1996), S. 2721-2728 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: In this study, Multimode boiling on a straight pin is theoretically investigated. Axial steady-state temperature distributions along the fin are numerically evaluated, as well as their linear stability characteristics. When film and transition boiling coexist on the fin surface, or only the transition boiling covers the entire fin, the operation remains stable only if the fin length is less than some critical value. When transition and nucleate boiling coexist on a fin, or the fin is in the three-mode boiling (film + transition + nucleate boiling), the entry of nucleate boiling at the fin tip stabilizes the boiling process. This study on base heat flow and fin efficiency with the stability criteria also suggests a new fin design methodology.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
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