ISSN:
1434-0879
Keywords:
Hematoporphyrin derivative
;
Photodynamic therapy
;
Phthalocyanines
;
Skin photosensitivity
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The potency of aluminum-chloro-tetrasulfonated phthalocyanine (AlS4Pc) as a photosensitizer in photodynamic therapy was evaluated in in vitro and in vivo studies. Compared with hematoporphyrin derivative (HpD), the following advantages of AlS4Pc were revealed: (1) AlS4Pc was less toxic than HpD in vitro without hight irradiation. (2) AlS4Pc showed more photodynamic-dependent cytotoxicity and anti-tumor effect in the red area of the spectrum (〉660 nm) at which tissue penetration is high. (3) AlS4Pc appeared to be removed more rapidly from normal tissues such as muscle and skin. (4) AlS4Pc showed less photodynamic-dependent cytotoxicity in vitro and milder cutaneous phototoxicity in vivo with UVA irradiation. On the basis of these observations, AlS4Pc shows considerable promise as a photosensitizer for PDT.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00307712
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