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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Intensive care medicine 16 (1990), S. 517-519 
    ISSN: 1432-1238
    Keywords: Malaria ; Exchange transfusion ; Tumour necrosis factor ; Corticosteroids
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A case of fulminant falciparum malaria with a 35% parasitaemia, shock and subcoma was treated successfully by using parenteral chemotherapy, exchange transfusion, dexamethasone, circulatory support and mechanical ventilation. Pathophysiology and complications of falciparum malaria are discussed. The treatment of severe malaria should aim for a fast reduction in parasitaemia and toxic products. An exchange transfusion can be additive to parenteral chemotherapy. Blocking the over-reacting cell-mediated immune response, aggressive shock treatment, prevention of secondary infections and maintaining normoglycaemia might reduce morbidity and mortality of fulminant falciparum malaria.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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  • 2
    Electronic Resource
    Electronic Resource
    New York, NY : Wiley-Blackwell
    International Journal of Chemical Kinetics 16 (1984), S. 1481-1494 
    ISSN: 0538-8066
    Keywords: Chemistry ; Physical Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Rates and thermodynamic data have been obtained for the reversible self-termination reaction: \documentclass{article}\pagestyle{empty}\begin{document}$${\rm R}^ \cdot + {\rm R}^ \cdot \mathop{\buildrel\longleftarrow\over\longrightarrow}^{2k1}_{2k_{-1}}D $$\end{document} Involving aromatic 2-(4′dimethylaminophenyl)indandione-1,3-yl (I), 2-(4′diphenylaminophenyl)indandione-1,3-yl (II), and 2,6 di-tert-butyl-4-(β-phthalylvinyl)-phenoxyl (III) radicals in different solvents. The type of solvent does not tangibly affect the 2k1 of Radical(I), obviously due to a compensation effect. The log(2k1) versus solvent parameter ET(30) curves for the recombination of radicals (II) and (III) have been found to be V shaped, the minimum corresponding to chloroform. The intensive solvation of Radical (II) by chloroform converts the initially diffusion-controlled recombination of the radical into an activated reaction. The log (2k-1) of the dimer of Radical (I) has been found to be a linear function of the Kirkwood parameter (ε - 1)/(2ε + 1), the dissociation rate increasing with the dielectic constant of the solvent. The investigation revealed an isokinetic relationship for the decay of the dimer of Radical (I), an isokinetic temperature β = 408 K and isoequilibrium relationship for the reversible recombination of Radical (I) with β° = 651 K. For Radical (I) dimer decay In(2k-1) = const + 0.8 In K, where K is the equilibrium constant of this reversible reaction. The transition state of Radical (I) dimer dissociation reaction looks more like a pair of radicals than the initial dimer. The role of specific solvation in radical self-termination reactions is discussed.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
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