ISSN:
1619-7089
Keywords:
Technetium 99m human immunoglobulin
;
Polyclonal human immunoglobulin (HIG)
;
Rheumatoid arthritis scintigraphy
;
Inflammation scintigraphy
;
Scintigraphic quantitation of synovitis
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The ability of technetium 99m labelled nonspecific, polyclonal human immunoglobulin G (99mTc-IgG) scintigraphy to depict and quantify synovial inflammation was studied in patients with rheumatoid arthritis (RA). Eight patients with clinically active synovitis were injected with 350 MBq 99mTc-IgG, and imaging took place 4 h later. This resulted in excellent images of inflamed synovium. Significant correlations were observed between individual joint uptake on the scan and scores for joint pain (n=316, p〈0.001), joint swelling (n = 300, p 〈 0.001) or the average of pain and swelling (n = 300, p 〈 0.001). These results suggest that 99mTc-IgG scintigraphy may provide an objective, non-invasive test to detect and measure synovitis.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00175915
Permalink