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  • 1
    Electronic Resource
    Electronic Resource
    Detection of a C-insertion polymorphism within the human tumor necrosis factor alpha (TNFA) gene (1995)
    Springer
    Human genetics 〈Berlin〉 96 (1995), S. 493-493 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract We have identified a C-insertion polymorphism in the 5'UTR of the first exon of the human tumor necrosis factor alpha (TNFA) gene. TNFA is a cytokine that plays an important role in the inflammatory response.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00191815
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  • 2
    Electronic Resource
    Electronic Resource
    Allele-specific quantification of TNFA transcripts in rheumatoid arthritis (1996)
    Springer
    Human genetics 〈Berlin〉 97 (1996), S. 813-818 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Clinical and laboratory studies have suggested a pivotal role for tumor necrosis factor alpha (TNFA) in the pathogenesis of rheumatoid arthritis (RA). Interindividual variation in the expression of TNFA indicates the existence of functionally distinct TNFA alleles that could play a role in susceptibility to TNFA-associated diseases such as RA. In order to determine whether differential TNFA gene expression is present in RA, we studied the relative contribution of TNFA alleles to the total amount of steady-state mRNA in peripheral blood mononuclear cells of RA patients and healthy individuals. Moreover, allelic TNFA mRNA expression was analyzed in synovial biopsy material of RA patients. For this purpose, we used the recently identified C-insertion polymorphism located in the 5′ untranslated region of the first exon. The location of this polymorphism within a part of the gene that is transcribed into mRNA allowed us to discriminate between the contribution of each allele to the total amount of TNFA mRNA in heterozygous individuals. The results of this study do not indicate the existence of variation at the level of mRNA transcribed from each TNFA allele by in vitro and physiological stimulation conditions in RA patients. Therefore, our data do not suggest a role for transcriptionally distinct TNFA alleles in the susceptibility to RA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004390050142
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Allele-specific quantification of TNFA transcripts in rheumatoid arthritis (1996)
    Springer
    Human genetics 〈Berlin〉 97 (1996), S. 813-818 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Clinical and laboratory studies have suggested a pivotal role for tumor necrosis factor alpha (TNFA) in the pathogenesis of rheumatoid arthritis (RA). Interindividual variation in the expression of TNFA indicates the existence of functionally distinct TNFA alleles that could play a role in susceptibility to TNFA-associated diseases such as RA. In order to determine whether differential TNFA gene expression is present in RA, we studied the relative contribution of TNFA alleles to the total amount of steady-state mRNA in peripheral blood mononuclear cells of RA patients and healthy individuals. Moreover, allelic TNFA mRNA expression was analyzed in synovial biopsy material of RA patients. For this purpose, we used the recently identified C-insertion polymorphism located in the 5′ untranslated region of the first exon. The location of this polymorphism within a part of the gene that is transcribed into mRNA allowed us to discriminate between the contribution of each allele to the total amount of TNFA mRNA in heterozygous individuals. The results of this study do not indicate the existence of variation at the level of mRNA transcribed from each TNFA allele by in vitro and physiological stimulation conditions in RA patients. Therefore, our data do not suggest a role for transcriptionally distinct TNFA alleles in the susceptibility to RA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02346195
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  • 4
    Electronic Resource
    Electronic Resource
    An extended HLA-DQ-DR haplotype rather than DRB1 alone contributes to RA predisposition (1998)
    Springer
    Immunogenetics 48 (1998), S. 394-401 
    Details
    ISSN: 1432-1211
    Keywords: Key words Rheumatoid arthritis ; HLA-DQ ; HLA-DR ; Protection ; Self-peptides
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract  In the present study, we tested our hypothesis on the role of a DQ-DR haplotype in rheumatoid arthritis (RA) predisposition. Using two groups of patients and controls, one from The Netherlands and one from Switzerland, we found that DQA1*0301-homozygous and DQA1*0301//DQA1*0101/04-heterozygous individuals are highly predisposed to RA in both populations, while DQA1*0101/04-homozygous are not. The DQA1*0301-DRB1*0403/06/07 and DQA1*0301-DRB1*0901 haplotypes are not associated with RA by themselves but strongly increase the risk of developing disease in DQA1*0301- and DQA1*0101/04-heterozygous. DRB1 alleles carrying the motif DERAA in their third hypervariable region, i.e., *0103, *0402, *1102, *1103, *1301, and *1302, provide a long-lasting protection against RA in DQA1*0101/04- but not in DQA1*0301-positive individuals. These data show that considering both DQ and DR gives a better distinction between patients and controls than the shared epitope hypothesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002510050450
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  • 5
    Electronic Resource
    Electronic Resource
    Evidence for Selective in Vivo Expansion of Synovial Tissue-Infiltrating CD4+CD45RO+ T-Lymphocytes on the Basis of CDR3 Diversity (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 756 (1995), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1995.tb44512.x
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  • 6
    Electronic Resource
    Electronic Resource
    Therapeutic Regulation of T Cells in Rheumatoid Arthritis (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Immunological reviews 144 (1995), S. 0 
    Details
    ISSN: 1600-065X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-065X.1995.tb00063.x
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  • 7
    Electronic Resource
    Electronic Resource
    Two-year follow-up of a randomized controlled trial of a clinical nurse specialist intervention, inpatient, and day patient team care in rheumatoid arthritis (2003)
    Oxford, UK : Blackwell Science Ltd
    Journal of advanced nursing 41 (2003), S. 0 
    Details
    ISSN: 1365-2648
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Aim.  To compare the long-term effectiveness of care delivered by a clinical nurse specialist (CNS) with inpatient team care and day patient team care in patients with rheumatoid arthritis and increasing functional limitations. Background.  The role of CNSs in the management of patients with rheumatoid arthritis (RA) is evolving, and their effectiveness in comparison with care provided by a rheumatologist alone has been established. However, long-term controlled studies showing how the effectiveness of CNSs compares with that of other forms of co-ordinated care, such as multidisciplinary team care, are lacking. Methods.  Two hundred and ten patients rheumatoid arthritis patients were randomized to care delivered by a CNS in a rheumatology outpatient clinic (12 weeks), inpatient team care (2 weeks) and day patient team care (3 weeks). Clinical assessments recorded on study entry, weeks 12, 26, 52, 78 and 104 comprised the health assessment questionnaire (HAQ) and MacMaster Toronto Arthritis (MACTAR) patient preference interview as primary outcome measures. Grip strength, walk test, RAND-36, Rheumatoid Arthritis Quality of Life questionnaire and disease activity score (DAS) were applied as secondary outcome measures. Results.  No significant differences in medical treatment, use of services of other health professionals, introduction of adaptive equipment or number of hospitalizations were observed between the three treatment groups during 2 year follow-up, except that visits to nurse specialists were more frequent and home help was less frequent in the CNS group. A comparison of clinical outcomes among the three groups and a comparison between the nurse specialist and inpatient and day patient care groups together did not show any significant differences. Within all three groups functional status, quality of life and disease activity improved significantly ( P 〈 0·05). In general, the results obtained after 12 weeks remained stable until 104 weeks after the start of the study. Conclusion.  Care provided by a CNS in an outpatient rheumatology clinic has a similar long-term clinical outcome to inpatient and day patient team care in patients with rheumatoid arthritis. A CNS intervention appears to be an effective innovation in the care for patients with rheumatoid arthritis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2648.2003.02503.x
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  • 8
    Electronic Resource
    Electronic Resource
    Measurement of synovial inflammation in rheumatoid arthritis with technetium 99m labelled human polyclonal immunoglobulin G (1991)
    Springer
    European journal of nuclear medicine 18 (1991), S. 119-123 
    Details
    ISSN: 1619-7089
    Keywords: Technetium 99m human immunoglobulin ; Polyclonal human immunoglobulin (HIG) ; Rheumatoid arthritis scintigraphy ; Inflammation scintigraphy ; Scintigraphic quantitation of synovitis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The ability of technetium 99m labelled nonspecific, polyclonal human immunoglobulin G (99mTc-IgG) scintigraphy to depict and quantify synovial inflammation was studied in patients with rheumatoid arthritis (RA). Eight patients with clinically active synovitis were injected with 350 MBq 99mTc-IgG, and imaging took place 4 h later. This resulted in excellent images of inflamed synovium. Significant correlations were observed between individual joint uptake on the scan and scores for joint pain (n=316, p〈0.001), joint swelling (n = 300, p 〈 0.001) or the average of pain and swelling (n = 300, p 〈 0.001). These results suggest that 99mTc-IgG scintigraphy may provide an objective, non-invasive test to detect and measure synovitis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00175915
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  • 9
    Electronic Resource
    Electronic Resource
    Measurement of synovial inflammation in rheumatoid arthritis with technetium 99m labelled human polyclonal immunoglobulin G (1991)
    Springer
    European journal of nuclear medicine 18 (1991), S. 119-123 
    Details
    ISSN: 1619-7089
    Keywords: Technetium 99m human immunoglobulin ; Polyclonal human immunoglobulin (HIG) ; Rheumatoid arthritis scintigraphy ; Inflammation scintigraphy ; Scintigraphic quantitation of synovitis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The ability of technetium 99m labelled nonspecific, polyclonal human immunoglobulin G (99mTc-IgG) scintigraphy to depict and quantify synovial inflammation was studied in patients with rheumatoid arthritis (RA). Eight patients with clinically active synovitis were injected with 350 MBq99mTc-IgG, and imaging took place 4 h later. This resulted in excellent images of inflamed synovium. Significant correlations were observed between individual joint uptake on the scan and scores for joint pain (n=316,p〈0.001), joint swelling (n = 300,p 〈 0.001) or the average of pain and swelling (n = 300,p 〈 0.001). These results suggest that99mTc-IgG scintigraphy may provide an objective, non-invasive test to detect and measure synovitis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00950757
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    Paper (German National Licenses)
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  • 10
    Electronic Resource
    Electronic Resource
    New agents for scintigraphy in rheumatoid arthritis (1995)
    Springer
    European journal of nuclear medicine 22 (1995), S. 1339-1346 
    Details
    ISSN: 1619-7089
    Keywords: Rheumatoid arthritis ; Human immunoglobulin ; Radiolabelled antibodies ; Somatostatin receptors ; J001
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Radiopharmaceuticals have been used as investigative tools for the detection and treatment of arthritis activity in rheumatoid arthritis (RA) since the 1950s. Against the background of the pathophysiology of RA, the current status of joint scintigraphy and possible future developments are reviewed. Both non-specific (radiolabelled leucocytes and technetium-99m labelled human immunoglobulin) and specific targeting radiopharmaceuticals (including radiolabelled antibodies) are considered. The use of radiopharmaceuticals in the detection of arthritis activity has the advantages of allowing direct imaging of joints by means of whole-body scintigraphy and of joints that are difficult to assess clinically or radiographically. Promising results have been obtained with radiolabelled anti-CD4 and anti-E-selectin antibodies and with somatostatin receptor imaging, but more data are available regarding99mTc-IgG scintigraphy, which differentiates between the various degrees of arthritis activity and thus facilitates the choice of antirheumatic drug. Newer promising approaches to the imaging of RA include the use of radiolabelled J001 and cytokines, though studies on these are limited at present.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00801624
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