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  • 1
    Digitale Medien
    Digitale Medien
    Evidence for Selective in Vivo Expansion of Synovial Tissue-Infiltrating CD4+CD45RO+ T-Lymphocytes on the Basis of CDR3 Diversity (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 756 (1995), S. 0 
    Details
    ISSN: 1749-6632
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Allgemeine Naturwissenschaft
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1749-6632.1995.tb44512.x
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  • 2
    Digitale Medien
    Digitale Medien
    Therapeutic Regulation of T Cells in Rheumatoid Arthritis (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Immunological reviews 144 (1995), S. 0 
    Details
    ISSN: 1600-065X
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1600-065X.1995.tb00063.x
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  • 3
    Digitale Medien
    Digitale Medien
    Two-year follow-up of a randomized controlled trial of a clinical nurse specialist intervention, inpatient, and day patient team care in rheumatoid arthritis (2003)
    Oxford, UK : Blackwell Science Ltd
    Journal of advanced nursing 41 (2003), S. 0 
    Details
    ISSN: 1365-2648
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Aim.  To compare the long-term effectiveness of care delivered by a clinical nurse specialist (CNS) with inpatient team care and day patient team care in patients with rheumatoid arthritis and increasing functional limitations. Background.  The role of CNSs in the management of patients with rheumatoid arthritis (RA) is evolving, and their effectiveness in comparison with care provided by a rheumatologist alone has been established. However, long-term controlled studies showing how the effectiveness of CNSs compares with that of other forms of co-ordinated care, such as multidisciplinary team care, are lacking. Methods.  Two hundred and ten patients rheumatoid arthritis patients were randomized to care delivered by a CNS in a rheumatology outpatient clinic (12 weeks), inpatient team care (2 weeks) and day patient team care (3 weeks). Clinical assessments recorded on study entry, weeks 12, 26, 52, 78 and 104 comprised the health assessment questionnaire (HAQ) and MacMaster Toronto Arthritis (MACTAR) patient preference interview as primary outcome measures. Grip strength, walk test, RAND-36, Rheumatoid Arthritis Quality of Life questionnaire and disease activity score (DAS) were applied as secondary outcome measures. Results.  No significant differences in medical treatment, use of services of other health professionals, introduction of adaptive equipment or number of hospitalizations were observed between the three treatment groups during 2 year follow-up, except that visits to nurse specialists were more frequent and home help was less frequent in the CNS group. A comparison of clinical outcomes among the three groups and a comparison between the nurse specialist and inpatient and day patient care groups together did not show any significant differences. Within all three groups functional status, quality of life and disease activity improved significantly ( P 〈 0·05). In general, the results obtained after 12 weeks remained stable until 104 weeks after the start of the study. Conclusion.  Care provided by a CNS in an outpatient rheumatology clinic has a similar long-term clinical outcome to inpatient and day patient team care in patients with rheumatoid arthritis. A CNS intervention appears to be an effective innovation in the care for patients with rheumatoid arthritis.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1365-2648.2003.02503.x
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  • 4
    Digitale Medien
    Digitale Medien
    Does cyclosporin A cause cancer? (1999)
    [s.l.] : Nature America Inc.
    Nature medicine 5 (1999), S. 714-714 
    Details
    ISSN: 1546-170X
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Medizin
    Notizen: [Auszug] To the editor—Hojo et al. described a tumor growth-promoting effect of the immunosuppressive drug cyclosporin A (CsA) in immunodeficient mice. The effect was attributed to the upregulation of the cytokine transforming growth factor beta by CsA. CsA is used not only in transplant medicine to ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/10417
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  • 5
    Digitale Medien
    Digitale Medien
    The cervical spine in rheumatoid arthritis: relationship between neurologic signs and morphology on MR imaging and radiographs (1996)
    Springer
    Skeletal radiology 25 (1996), S. 113-118 
    Details
    ISSN: 1432-2161
    Schlagwort(e): Key words Rheumatoid arthritis ; Cervical spine ; Cervical myelopathy ; Magnetic resonance imaging
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract  Objective. Comparison of clinically observed neurologic long tract signs in a heterogeneous group of patients with rheumatoid arthritis (RA), with morphologic abnormalities of the cervical spine as depicted on radiographs and magnetic resonance (MR) images. Design. The patients were prospectively assigned to one of three classes on the basis of their neurologic status. Lateral cervical spine radiographs and sagittal T1-weighted and gradient echo images were performed. The qualitative MR features evaluated were erosion of the dens and atlas, brain stem compression, subarachnoid space encroachment, pannus around the dens, appearance of the fat body caudal to the clivus, and the signal intensity of the pannus. The quantitative imaging parameters were the cervicomedullary angle and the distance of the dens to the line of McRae. Patients. Sixty-three consecutive patients with RA and subjective symptoms, especially neck or occipital pain, and/or clinical objective signs consistent with a compromised cervical cord were included in this study. Results and conclusions. Damage documented with radiographs and MR imaging in patients with RA is often severe, even in those without neurologic signs (class 1). None of the abnormalities confined to the atlantoaxial level correlated significantly with neurologic classification. Subarachnoid space encroachment anywhere in the entire cervical spine did correlate significantly with neurologic classification.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s002560050046
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  • 6
    Digitale Medien
    Digitale Medien
    Allele-specific quantification of TNFA transcripts in rheumatoid arthritis (1996)
    Springer
    Human genetics 〈Berlin〉 97 (1996), S. 813-818 
    Details
    ISSN: 1432-1203
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Abstract Clinical and laboratory studies have suggested a pivotal role for tumor necrosis factor alpha (TNFA) in the pathogenesis of rheumatoid arthritis (RA). Interindividual variation in the expression of TNFA indicates the existence of functionally distinct TNFA alleles that could play a role in susceptibility to TNFA-associated diseases such as RA. In order to determine whether differential TNFA gene expression is present in RA, we studied the relative contribution of TNFA alleles to the total amount of steady-state mRNA in peripheral blood mononuclear cells of RA patients and healthy individuals. Moreover, allelic TNFA mRNA expression was analyzed in synovial biopsy material of RA patients. For this purpose, we used the recently identified C-insertion polymorphism located in the 5′ untranslated region of the first exon. The location of this polymorphism within a part of the gene that is transcribed into mRNA allowed us to discriminate between the contribution of each allele to the total amount of TNFA mRNA in heterozygous individuals. The results of this study do not indicate the existence of variation at the level of mRNA transcribed from each TNFA allele by in vitro and physiological stimulation conditions in RA patients. Therefore, our data do not suggest a role for transcriptionally distinct TNFA alleles in the susceptibility to RA.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02346195
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  • 7
    Digitale Medien
    Digitale Medien
    An extended HLA-DQ-DR haplotype rather than DRB1 alone contributes to RA predisposition (1998)
    Springer
    Immunogenetics 48 (1998), S. 394-401 
    Details
    ISSN: 1432-1211
    Schlagwort(e): Key words Rheumatoid arthritis ; HLA-DQ ; HLA-DR ; Protection ; Self-peptides
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Abstract  In the present study, we tested our hypothesis on the role of a DQ-DR haplotype in rheumatoid arthritis (RA) predisposition. Using two groups of patients and controls, one from The Netherlands and one from Switzerland, we found that DQA1*0301-homozygous and DQA1*0301//DQA1*0101/04-heterozygous individuals are highly predisposed to RA in both populations, while DQA1*0101/04-homozygous are not. The DQA1*0301-DRB1*0403/06/07 and DQA1*0301-DRB1*0901 haplotypes are not associated with RA by themselves but strongly increase the risk of developing disease in DQA1*0301- and DQA1*0101/04-heterozygous. DRB1 alleles carrying the motif DERAA in their third hypervariable region, i.e., *0103, *0402, *1102, *1103, *1301, and *1302, provide a long-lasting protection against RA in DQA1*0101/04- but not in DQA1*0301-positive individuals. These data show that considering both DQ and DR gives a better distinction between patients and controls than the shared epitope hypothesis.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s002510050450
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  • 8
    Digitale Medien
    Digitale Medien
    Allele-specific quantification of TNFA transcripts in rheumatoid arthritis (1996)
    Springer
    Human genetics 〈Berlin〉 97 (1996), S. 813-818 
    Details
    ISSN: 1432-1203
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Abstract Clinical and laboratory studies have suggested a pivotal role for tumor necrosis factor alpha (TNFA) in the pathogenesis of rheumatoid arthritis (RA). Interindividual variation in the expression of TNFA indicates the existence of functionally distinct TNFA alleles that could play a role in susceptibility to TNFA-associated diseases such as RA. In order to determine whether differential TNFA gene expression is present in RA, we studied the relative contribution of TNFA alleles to the total amount of steady-state mRNA in peripheral blood mononuclear cells of RA patients and healthy individuals. Moreover, allelic TNFA mRNA expression was analyzed in synovial biopsy material of RA patients. For this purpose, we used the recently identified C-insertion polymorphism located in the 5′ untranslated region of the first exon. The location of this polymorphism within a part of the gene that is transcribed into mRNA allowed us to discriminate between the contribution of each allele to the total amount of TNFA mRNA in heterozygous individuals. The results of this study do not indicate the existence of variation at the level of mRNA transcribed from each TNFA allele by in vitro and physiological stimulation conditions in RA patients. Therefore, our data do not suggest a role for transcriptionally distinct TNFA alleles in the susceptibility to RA.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s004390050142
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  • 9
    Digitale Medien
    Digitale Medien
    Detection of a C-insertion polymorphism within the human tumor necrosis factor alpha (TNFA) gene (1995)
    Springer
    Human genetics 〈Berlin〉 96 (1995), S. 493-493 
    Details
    ISSN: 1432-1203
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Abstract We have identified a C-insertion polymorphism in the 5'UTR of the first exon of the human tumor necrosis factor alpha (TNFA) gene. TNFA is a cytokine that plays an important role in the inflammatory response.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00191815
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  • 10
    Digitale Medien
    Digitale Medien
    Measurement of synovial inflammation in rheumatoid arthritis with technetium 99m labelled human polyclonal immunoglobulin G (1991)
    Springer
    European journal of nuclear medicine 18 (1991), S. 119-123 
    Details
    ISSN: 1619-7089
    Schlagwort(e): Technetium 99m human immunoglobulin ; Polyclonal human immunoglobulin (HIG) ; Rheumatoid arthritis scintigraphy ; Inflammation scintigraphy ; Scintigraphic quantitation of synovitis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The ability of technetium 99m labelled nonspecific, polyclonal human immunoglobulin G (99mTc-IgG) scintigraphy to depict and quantify synovial inflammation was studied in patients with rheumatoid arthritis (RA). Eight patients with clinically active synovitis were injected with 350 MBq 99mTc-IgG, and imaging took place 4 h later. This resulted in excellent images of inflamed synovium. Significant correlations were observed between individual joint uptake on the scan and scores for joint pain (n=316, p〈0.001), joint swelling (n = 300, p 〈 0.001) or the average of pain and swelling (n = 300, p 〈 0.001). These results suggest that 99mTc-IgG scintigraphy may provide an objective, non-invasive test to detect and measure synovitis.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00175915
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