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  • 1
    Electronic Resource
    Electronic Resource
    Effects of caloric restriction on rodent drug and carcinogen metabolizing enzymes: implications for mutagenesis and cancer
    Amsterdam : Elsevier
    Mutation Research DNAging 295 (1993), S. 201-222 
    Details
    ISSN: 0921-8734
    Keywords: Caloric restriction ; Cytochrome P450 ; Drug metabolism
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0921-8734(93)90021-T
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  • 2
    Electronic Resource
    Electronic Resource
    Induction and suppression of renal and hepatic cytochrome P450-dependent monooxygenases by acute and chronic streptozotocin diabetes in hamsters (1996)
    Springer
    Archives of toxicology 70 (1996), S. 202-208 
    Details
    ISSN: 1432-0738
    Keywords: Key words Diabetes ; Cytochrome P450 ; Monooxygenase ; Hamster ; Streptozotocin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The acute and chronic effects of streptozotocin diabetes on kidney and liver microsomal monooxygenases were studied using hamsters 2 days and 6 weeks following treatment with the diabetogen, respectively. Acute diabetes increased aniline hydroxylation and N-nitrosodimethylamine demethylation, decreased pentoxyresorufin O-dealkylation, without affecting benzo(a)pyrene hydroxylation and 7-ethoxycoumarin O-deethylation in kidney and liver microsomes. The effects of chronic diabetes on the microsomal monooxygenases were similar to the effects of acute diabetes, except that the chronic diabetic condition markedly decreased benzo(a)pyrene and 7-ethoxycoumarin oxidations in kidney microsomes. Total cytochrome P450 content and NADPH-cytochrome P450 reductase activity in kidney and liver microsomes of the diabetic hamsters were similar to the controls. Gel electrophoresis of microsomes from control and streptozoptocin treated hamster tissues revealed that diabetes enhanced the intensity of protein band(s) in the P450 molecular weight region. Immunoblotting of microsomal proteins showed that acute and chronic streptozotocin diabetes induced proteins immunorelated to P450s 2E1 and 1A in kidney and liver. In marked contrast, the acute and chronic diabetic conditions decreased the level of a P450 2B-immunorelated protein(s) in kidney and liver. The present study demonstrates that acute and chronic streptozotocin diabetes has the ability to induce P450 2E1 and 1A and suppress P450 2B in hamster kidney and liver and that the hamster monooxygenase responds to diabetes differently from the rat enzyme.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002040050261
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  • 3
    Electronic Resource
    Electronic Resource
    The effect of mixing on the modes of dispersion and rheological properties of two-phase polymer blends in extrusion (1975)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 19 (1975), S. 2831-2843 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: An experimental study was carried out to investigate the effect of mixing on the state of dispersion and rheological properties in the two-phase flow of polymer blends. For the study, blends of polystyrene and polypropylene were used, and two mixing devices were employed: a single-screw extruder combined with a “static mixer,” and a twin-screw compounding machine. Materials of various blending ratios were extruded at a constant temperature (200°C) through a capillary die having an L/D ratio of 20 (D = 0.125 in.). The state of dispersion in the two-phase system was investigated from pictures taken of the microstructure of the extrudate samples. It was found that different mixing devices have a profound influence on the state of dispersion of one polymer in another. Also determined were the rheological properties of the two-phase system investigated, from wall normal stress measurements. Our results show that, when shear stress is used as a parameter, the melt viscosity goes through a minimum, whereas the melt elasticity goes through a maximum. This is regardless of the type of mixing device employed, although the shapes of the curves are affected by the type employed. It is suggested that shear stress, instead of shear rate, be used in correlating the viscoelastic properties of two-phase polymer systems.
    Additional Material: 15 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1975.070191019
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  • 4
    Electronic Resource
    Electronic Resource
    Morphology and mechanical properties of injection-molded specimens of two-phase polymer blends (1977)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 21 (1977), S. 353-370 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: An experimental study was carried out to investigate the moldability of polymer blends which form two phases in the molten state and the effect of mixing on the morphology and mechanical porperties of molded specimens. Blends of polystyrene with polypropylene and blends of polystyrene with high-density polyethylene were used for this study. A plunger-type injection molding machine (Van Dorn) was employed for molding specimens. To improve the mixing performance of the plunger machine, a Static Mixer (Kenics Corp., Super Nozzle) was installed between the heating cylinder and the sprue. A number of different molding conditions (injection pressure, temperature, injection time, cooling time) were varied, and molded specimens were collected under each molding condition. The specimens were used for studying the degree of dispersion in the blends and for determining the mechanical properties. A differential thermal analysis (DTA) experiment was also carried out to determine the degree of dispersion of the blends in molded specimens. It was found that a linear correlation exists between the blend composition and thermal spectra area of the blends tested.
    Additional Material: 18 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1977.070210205
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  • 5
    Electronic Resource
    Electronic Resource
    Diffusion and solubility of some azo dyes in swollen gelatin matrices: The effects of dye size, matrix swell, and dye-matrix interactions (1985)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 30 (1985), S. 2075-2094 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: The diffusion coefficient (D) and the solubility coefficient (K) of three sulfonated azo dyes were measured in swollen gelatin membranes at pH 12 by two techniques (time lag and desorption rate), with good agreement between the two. A strong correlation was established between log D and the reciprocal of the free volume of the matrix. Hence, as free volume of the matrix increased (due to increasing solvent imbibition), dye mobility increased. As dye size increased, however, mobility decreased. Dye affinity for gelatin, as measured in dilute solutions by dynamic dialysis, was small and could be related to the dye solubility in more concentrated gelatin matrices. Increasing ionic strength or decreasing alcohol content increased K without affecting the dye mobility. On the other hand, the presence of polymers with strong affinity for the dye anions, e.g., polyvinylpyrrolidone, immobilized a large fraction of the dye ions and greatly slowed the overall dye transport.
    Additional Material: 14 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1985.070300524
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  • 6
    Electronic Resource
    Electronic Resource
    Catalysis of carbamate reactions by cyclic sulfonium zwitterions (1977)
    New York : Wiley-Blackwell
    Die Makromolekulare Chemie 178 (1977), S. 2127-2130 
    Details
    ISSN: 0025-116X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/macp.1977.021780727
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  • 7
    Electronic Resource
    Electronic Resource
    Translational diffusion of polystyrene in cyclohexane at infinite dilution from 283 to 348 K (1985)
    New York : Wiley-Blackwell
    Journal of Polymer Science: Polymer Physics Edition 23 (1985), S. 2457-2468 
    Details
    ISSN: 0098-1273
    Keywords: Physics ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: The translational diffusion coefficients are reported for polystyrenes with molecular weights 2000, 4000, and 9000 in cyclohexane at infinite dilution from 283.2 to 348.2 K. The results suggest that the hydrodynamic radii stay constant to within ±3% and that the real chain for molecular weight 9000 at 308.2 K is well represented by a Gaussian or Monte Carlo model involving the idea of statistical steps. Furthermore, the success of Hildebrand's free-volume empiricism has led to a correlation between Dμ0/T and M which represents the observed diffusivities to within ±2%.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pol.1985.180231204
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  • 8
    Electronic Resource
    Electronic Resource
    Catalysis of ureylene group formation by cyclic sulfonium zwitterions (1978)
    New York : Wiley-Blackwell
    Die Makromolekulare Chemie 179 (1978), S. 527-530 
    Details
    ISSN: 0025-116X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/macp.1978.021790228
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  • 9
    Electronic Resource
    Electronic Resource
    Small-angle neutron scattering study of the structure of protein / detergent complexes (1990)
    New York : Wiley-Blackwell
    Biopolymers 29 (1990), S. 335-346 
    Details
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Small-angle neutron scattering (SANS) was used to study the structure of protein/sodium dodecylsulfate complexes. Two water soluble proteins, bovine serum albumin (BSA) and ovalbumin (OVA), were used. The protein concentration was kept constant at 1 wt %, and protein/detergent wt ratio varied between 1/1, 1/1.5, 1/2 and 1/3. Absolute intensities of SANS distributions were analyzed by a fractal model. Analyses of large Q portions of SANS distributions established that sodium dodecylsulfate (SDS) molecules bound to a protein/SDS complex form micelle-like clusters. On the other hand, analyses of small Q portions of SANS distributions clearly showed that the arrangement of micelle-like clusters resembles a fractal packing of spheres. We showed that a protein/SDS complex can be characterized by four parameters extracted from the scattering experiment, namely, the average micelle size and its aggregation number, the fractal dimension characterizing the conformation of the micellar chains, the correlation length giving the extent of the unfolded polypeptide chains, and the numbers of micelle-like clusters in the complex.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bip.360290206
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  • 10
    Electronic Resource
    Electronic Resource
    SANS studies of concentrated protein solutions. I. Bovine serum albumin (1986)
    New York : Wiley-Blackwell
    Biopolymers 25 (1986), S. 1157-1175 
    Details
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Small-angle neutron scattering (SANS) was used to examine concentrated bovine serum albumin solutions of up to 20% protein w/v. At higher protein concentrations, scattering data show distinct features that can be ascribed to strong intermolecular interactions. Differential scattering cross-sections are fitted to a theoretical model of interparticle potential consisting of a hard core plus an exponentially decaying “tail.” For moderate ionic strength (0.03M K Acetate, pH 5.9), the intermolecular interaction agrees with the double-layer repulsive part of the well-known DLVO (Derjaguin, Landau, Verwey, Overbeek) theory for interacting colloidal particles. We thus demonstrate that it is possible to determine size parameters and the surface charge of protein molecules in dense solutions. At high salt concentrations (≥0.2M NaCl) data can be fitted by the same potential model, although interpretation in terms of DLVO theory is not possible. Even in this case, however, “effective” molecular size and potential parameters can be determined.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bip.360250613
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