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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Archives of sexual behavior 20 (1991), S. 17-25 
    ISSN: 1573-2800
    Keywords: aging ; libido ; erections ; intercourse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Psychology
    Notes: Abstract To gather data on sexuality, specifically in male veterans, and to test the hypothesis that aged males remain interested in sexual intercourse yet suffer from erectile failure, veterans age 30 to 99 were surveyed. The mailed survey had 88 questions and was pretested on young potent males and aged impotent males. From 1031 randomly selected subjects, there were 806 replies: 427 completed surveys, 247 refusals, and 132 who were too ill to participate (225 failed to reply). Among responders, sexual interest declined from a mean of 4.4/5 (4 = very interested, 5 = extremely interested) in men age 30–39 years to 2.0/5 (2 = slightly interested) in men age 90–99 (p 〈 0.0001). Vaginal intercourse was consistently the preferred sexual activity; however, intercourse frequency was diminished from a mean of once per week in 30- to 39-year-olds to once per year in 90- to 99-year-olds (p 〈 0.0001). Frequency, rigidity, and duration of erections were less in aged compared to younger cohorts (p 〈 0.0001). With these facts in mind, further research to bridge the libido-potency gap is warranted.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A series of Melanin-concentrating hormone (MCH) fragments have been synthesized and their biological activities compared with the parent peptide. The substructural units, 5-14 linear and 5-14 cyclic, have been used as models for MCH -  in 1H-nmr conformational studies. Conformational features predicted by molecular dynamics analyses find support in the nmr experiments.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Molecular dynamics simulations have been used to search for the accessible conformations of the melanin-concentrationg hormone (MCH). The studies have been performed on native MCH and two of its peptide fragments, a cyclic MCH(5-14) fragment and a linear MCH(5-14) fragment. An analysis of the molecular dynamics trajectories of the three peptides indicates that two regions of the peptide have characteristic conformational properties that may be important for the biological activity. One is a region around Gly8, which is conformationally mobile, and the other is around Pro13, which shows unusual rigidity. The molecular dynamics simulation results are discussed in terms of backbone structural features like β turns, side-chain interactions, and orientations of the disulfide bridge. The results of this analysis are used to suggest new analogues that will modify the conformational features of the peptide and further define the conformational requirements for activity. Finally, the results are related to nmr studies of the peptide and reveal agreements between the experimental nuclear Overhauser effect constraints and some of the accessible conformations obtained from the simulation.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
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