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Digitale Medien

Low conductance states of a single ion channel are not ‘closed’ (1995)

Korchev, Y. E. ; Bashford, C. L. ; Alder, G. M. ; [weitere]

Springer

The journal of membrane biology 147 (1995), S. 233-239

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Details

ISSN: 1432-1424

Schlagwort(e): Alpha toxin ; Channel size ; Conductance states ; Planar bilayer ; Polymer exclusion ; Staphylococcus aureus

Quelle: Springer Online Journal Archives 1860-2000

Thema: Biologie , Chemie und Pharmazie

Notizen: Abstract We have used a polymer-exclusion method to estimate the sizes of the high and low-conductance states of Staphylococcus aureus α-toxin channels across planar lipid bilayers. Despite a 〉10-fold difference in conductance between high and low-conductance states, the size differs by 〈2-fold. We conclude that factors other than the dimensions have a strong influence on the conductance of α-toxin channels. We also show that the high conductance state is destabilized by the presence of high molecular weight polymers outside the channel, compatible with the removal of channel water as the high conductance state “shrinks” to the low conductance state.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00234521

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