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  • 1
    Electronic Resource
    Electronic Resource
    Rat folic acid reductase activity during the perinatal period, in newborns, and after trimethoprim administration (1972)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 274 (1972), S. 229-237 
    Details
    ISSN: 1432-1912
    Keywords: Rat Folic Acid Reductase ; Pregnancy ; Fetus ; Newborns ; Trimethoprim
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The folic acid reductase activity in various organs of adult rats was studied in comparison to pregnant females (20th day of gestation) and fetal rats. The enzyme activities in the tissues of pregnant rats were in general about 30% higher than in normal adults. Fetal rats also possess the ability to catalyze the reduction of dihydrofolic acid, but it is evident that the liver and kidney have a considerably reduced capacity to form tetrahydrofolate. The folic acid reductase activity in liver and kidney rises for 10 days after birth and then declines to normal enzyme levels by the 4th week of life. Further studies concerning the interaction between trimethoprim and folic acid reductase in adult rats demonstrate that an oral dose of 5 or 50 mg/kg results in about a 30% increase of folic acid reductase activity in liver and kidney. The experiments suggest that there is a stimulation of enzyme synthesis following trimethoprim administration; because, the trimethoprim induced increase of the reductase activity is blocked by the administration of either puromycin or actinomycin D.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00501932
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Inhibition of rat folic acid reductase activity by trimethoprim during the later stages of gestation (1973)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 278 (1973), S. 227-230 
    Details
    ISSN: 1432-1912
    Keywords: Trimethoprim ; Rat Folic Acid Reductase ; Pregnancy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The increased level of folic acid reductase activity in rats during the perinatal period is inhibited following the oral administration of 5 or 50 mg/kg Trimethoprim. When the enzyme activity was tested in vitro, the highest sensitivity to the antimetabolite was displayed by the liver reductase isolated from rats the 20th day of pregnancy, the lowest was observed in the foetal liver extract. It is proposed that the stimulated reductase activity during the pregnancy is caused by a newly synthesized, Trimethoprim-sensitive enzyme form. The results of the in vitro experiments could contribute to the suggested hypothesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00500653
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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