ISSN:
1432-1041
Keywords:
Prostaglandin E1
;
Cardiopulmonary bypass
;
cardiac surgery
;
renal function
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary We have evaluated the effect of prostaglandin E1(PGE1) on renal function after cardiac surgery with cardiopulmonary bypass in 20 patients, ten of whom received 0.02 μg·kg−1·min−1 of PGE1 by infusion into the oxygenator during bypass; ten patients served as controls. Serum β2-microglobulin fell significantly and urine β2-microglobulin increased significantly after surgery in both groups. Urine N-acetyl-β-D-glucosaminidase was high after surgery in both groups, but it was significantly lower in the PGE1 group. Free water clearance fell significantly on the 1st, 3rd, and 5th postoperative days compared with preoperative values in the control but not in the PGE1 group. These results suggest that PGE1 may prevent renal dysfunction after cardiopulmonary bypass.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00315386
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