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  • 1
    Electronic Resource
    Electronic Resource
    Alpha 2-macroglobulin synthesis in interleukin-6-stimulated human neuronal (SH-SY5Y neuroblastoma) cells Potential significance for the processing of Alzheimer β-amyloid precursor protein
    Amsterdam : Elsevier
    FEBS Letters 282 (1991), S. 127-131 
    Details
    ISSN: 0014-5793
    Keywords: Alpha 2-macroglobulin ; Alzheimer's disease ; Amyloid precursor protein ; Interleukin-6 ; Neuron
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0014-5793(91)80460-K
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Interleukin-6 and α-2-macroglobulin indicate an acute-phase state in Alzheimer's disease cortices
    Amsterdam : Elsevier
    FEBS Letters 285 (1991), S. 111-114 
    Details
    ISSN: 0014-5793
    Keywords: Acute phase ; Alzheimer's disease ; Interleukin-6 ; Protease inhibitor ; α-2-Macroglobulin
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0014-5793(91)80737-N
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    In-vitro matured human macrophages express Alzheimer's βA4-amyloid precursor protein indicating synthesis in microglial cells
    Amsterdam : Elsevier
    FEBS Letters 282 (1991), S. 335-340 
    Details
    ISSN: 0014-5793
    Keywords: Alzheimer's disease ; Amyloid precursor protein ; Macrophage ; Microglia
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0014-5793(91)80508-Z
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Die Behandlung des atopischen Ekzems in interdisziplinärer Zusammenarbeit zwischen Dermatologie und Psychosomatik Eine Einzelfalldarstellung (1996)
    Springer
    Der Hautarzt 47 (1996), S. 628-633 
    Details
    ISSN: 1432-1173
    Keywords: Schlüsselwörter Atopisches Ekzem ; Nahrungsmittelallergie ; Psychosomatik ; Mutter-Kind-Beziehung ; Key words Atopic eczema ; Food allergy ; Psychosomatics ; Mother-child relationship
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Atopic eczema is one of the most frequent dermatological diseases, with a still increasing incidence. Although its etiopathogenesis is still not completely understood, a variety of triggering factors are known. The following case report describes the clinical course of atopic dermatitis in a 2-year-old boy in whom both IgE-mediated allergic reactions and psychological factors were involved in triggering and maintenance of skin lesions. This demonstrates how important both dermatological therapy and close cooperation with the field of psychosomatic medicine can be.
    Notes: Zusammenfassung Das atopische Ekzem zählt zu den häufigsten dermatologischen Erkrankungen mit zunehmender Inzidenz. Obwohl die Ätiopathogenese letztendlich ungeklärt ist, sind eine Vielzahl auslösender Faktoren bekannt. Anhand der Falldarstellung eines 2jährigen Kindes, bei dem sowohl IgE-vermittelte allergische Reaktionen als auch psychische Faktoren an der Auslösung und Unterhaltung der Hautveränderungen beteiligt waren, soll aufgezeigt werden, daß eine erfolgreiche Behandlung des atopischen Ekzems in vielen Fällen neben dermatologisch-allergologischen Therapieansätzen ebenso eine enge Kooperation mit dem Fachgebiet der Psychosomatik erforderlich macht.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001050050480
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  • 5
    Electronic Resource
    Electronic Resource
    Inflammatory mechanisms in Alzheimer's disease (1996)
    Springer
    European archives of psychiatry and clinical neuroscience 246 (1996), S. 124-128 
    Details
    ISSN: 1433-8491
    Keywords: Senile plaques ; Primitive plaques ; Alzheimer's disease ; Interleukin-6
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In recent years many studies have indicated an involvement of inflammatory mechanisms in Alzheimer's disease (AD). Acute-phase proteins such as α1-antichymotrypsin and c-reactive protein, elements of the complement system, and activated microglial and astroglial cells are consistently found in brains of AD patients. Most importantly, also cytokines such as interleukin-6 (IL-6) have been detected in the cortices of AD patients, indicating a local activation of components of the unspecific inflammatory system. Up to now it has remained unclear whether inflammatory mechanisms represent a primary event or only an unspecific reaction to brain tissue damage. Therefore, we investigated whether IL-6 immunoreactivity could be found in plaques prior to the onset of neuritic changes, or whether the presence of this cytokine is restricted to later stages of plaque pathology. we confirmed our previous observation that IL-6 is detectable in a significant proportion of plaques in the brains of demented patients. In AD patients IL-6 was found in diffuse plaques in a significant higher ratio as would have been expected from a random distribution of IL-6 among all plaque types. This observation suggests that IL-6 may precede neuritic changes, and that immunological mechanism may be involved both in the transformation from diffuse to neuritic plaques in AD and in the development of dementia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02189112
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Psychosomatische Grundversorgung auf der Grundlage des PLISSIT-Modells Entwicklung und Evaluation einer Weiterbildungskonzeption (1999)
    Springer
    Der Nervenarzt 70 (1999), S. 54-63 
    Details
    ISSN: 1433-0407
    Keywords: Schlüsselwörter Psychosomatische Grundversorgung ; Fortbildung ; Hausärzte ; Beratung ; Psychiatrie ; Psychosomatik ; Key words Education ; Training program ; General practioners ; Psychosomatic medicine ; Psychiatry ; Primary care ; Continuous medical education
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Deficits in current approaches of psychosomatic and psychiatric education for general practitioners are reviewed. A skill-based training was developed in line with the four step counceling approach of the „PLISSIT” approach: The GP helps in first step („permission”) the patient to accept his problem and assesses informations about causing and maintaining factors of his symptomatology. In the second step he should provide information about the disorder and reverse misunderstanding and passivity (Limited Information). The GP’s should develop preliminary strategies for change in the third step („coping strategies”, „symptom management”; „special suggestions”) and preparate the intensive phase of therapy as the last step. First results of the evaluation of the training program are presented demonstrate the effectiveness and acceptance of the education programm.
    Notes: Zusammenfassung Ausgehend von einer Analyse der Schwächen aktueller Ansätze der psychosomatischen Grundversorgung wird einerseits ein Ansatz vorgestellt, der störungsspezifisch im Rahmen eines Mehrebenenmodells pharmakologische und verbale Intervention aufeinander bezieht. Andererseits werden im Sinne eines zeitökonomisch abgestuften Vorgehens verschiedene Phasen durch das zugrundegelegte PLISSIT-Modell differenziert: In der Permission-Phase geht es um die Akzeptanzvermittlung und Problemanalyse hinsichtlich der vom Patienten geschilderten Beschwerden, in der Phase der „limited information” um die dialogische Erarbeitung eines Störungsmodells und den Aufbau einer aktiven Änderungsmotivation, in der Phase der „special suggestions” erfolgt eine konkrete Anleitung zur Selbstbeobachtung und -protokollierung des Problemverhaltens sowie die Vermittlung von Strategien zum Symptommanagement; in der letzten Phase der „intensive therapy” geht es um die Indikationsstellung und den Motivationsaufbau zur fachärztlichen bzw. fachpsychotherapeutischen Weiterbehandlung. Empirische Ergebnisse zur Evaluation des Weiterbildungskonzeptes an über 200 Teilnehmern werden referiert.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001150050400
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Psychosexual counseling and specific interventions in psychogenic erectile dysfunction (1999)
    Springer
    Reproduktionsmedizin 15 (1999), S. 285-293 
    Details
    ISSN: 1434-808X
    Keywords: Schlüsselwörter Erektile Dysfunktion ; psychogene Erektionsstörungen ; Sexualtherapie ; Psychotherapie ; Psychosomatik ; Kombination psychotherapeutischer und medikamentöser Verfahren ; Key words Erectile dysfunction ; Psychogenic causes ; Sex therapy ; Psychotherapy ; Psychosomatics ; Combination therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary In the light of highly successful somatic therapies psychotherapeutic interventions in erectile dysfunction are nowadays less considered. But they are nevertheless highly effective and needed according to the psycho-somatic nature of the condition. In this article we present an etiologic framework of psychogenic erectile dysfunction as well as the diagnostic approach and therapeutic interventions. Finally we discuss the need for an increased research in the combination of psychotherapeutic and medical therapy.
    Notes: Zusammenfassung Angesichts großer Erfolge in der medikamentösen Behandlung der erektilen Dysfunktion haben psychotherapeutische Interventionen in letzter Zeit wenig Aufmerksamkeit erhalten. Doch ist bei Erektionsstörungen als psycho-physisches Gesamtgeschehen auch die Kenntnis psychologischer Faktoren für eine erfolgreiche Behandlung nötig. Die vorliegende Arbeit stellt grundlegende ätiologische Konzepte psychogener Erektionsstörungen vor, erläutert die psychologische Diagnostik und die gängigen Modelle für Sexualberatung und Sexualtherapie. Schließlich wird die Möglichkeit einer Kombination von medikamentöser und psychotherapeutischer Behandlung diskutiert.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004440050087
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