Bibliothek

X
feed icon rss

Ihre E-Mail wurde erfolgreich gesendet. Bitte prüfen Sie Ihren Maileingang.

Leider ist ein Fehler beim E-Mail-Versand aufgetreten. Bitte versuchen Sie es erneut.

Vorgang fortführen?

Exportieren
Filter
  • Push-pull cannula  (2)
  • Superfusion  (2)
  • Bathtub death, skin mark  (1)
  • 1
    Digitale Medien
    Digitale Medien
    In vivo release of endogenous GABA in the cat hypothalamus (1979)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 308 (1979), S. 143-147 
    Details
    ISSN: 1432-1912
    Schlagwort(e): Hypothalamus ; GABA release ; Superfusion ; Electrical stimulation ; Potassium chloride ; Locus coeruleus
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The posterior hypothalamus of anaesthetized cats was superfused with artificial cerebrospinal fluid through a push-pull cannula and the release of endogenous GABA from the hypothalamus into the superfusate was studied. The resting release of GABA varied rhythmically, since phases of high rate of release were separated from each other by phases of low rate of release. The time interval between two adjacent phases of high rate of release was about 70 min. Electrical stimulation of the posterior hypothalamus with the tip of the cannula enhanced the rate of release of GABA in a frequency-dependent way. Superfusion of the hypothalamus with CSF which contained a high concentration of potassium and a low concentration of sodium increased the rate of release of GABA; this effect was dependent on the presence of calcium ions in the superfusing fluid. Pretreatment of the cats with reserpine reduced the levels of GABA in hypothalamus and rest of brain and the concentration of GABA in the superfusate as well. Stimulation of the locus coeruleus with a bipolar electrode elicited an increased release of GABA in the hypothalamus.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00499056
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Artikel (Nationallizenzen)
    Volltext
  • 2
    Digitale Medien
    Digitale Medien
    Effects of short-lasting and long-lasting blood pressure changes on the release of endogenous catecholamines in the hypothalamus of the conscious, freely moving rabbit (1983)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 322 (1983), S. 203-209 
    Details
    ISSN: 1432-1912
    Schlagwort(e): Endogenous catecholamines ; Push-pull cannula ; Rhythmic release ; Blood pressure ; Hypothalamus ; Conscious rabbit
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary In anaesthetized rabbits guide cannulae were stereotaxically inserted into the anterior hypothalamic area and into the posterior hypothalamic nucleus. Additionally, catheters were inserted into the carotid artery and the jugular vein. Some days after the operation push-pull cannulae were inserted through the guide cannulae into the hypothalamic regions of the conscious, freely moving animal. The areas were superfused with artificial CSF and the release of the endogenous catecholamines dopamine, noradrenaline and adrenaline was determined in the superfusates. In the two hypothalamic regions the resting release of the catecholamines rhythmically varied with time at approximately 70 min cycles. A rise in blood pressure induced by the intravenous injection of noradrenaline or tramazoline enhanced the rates of release of the catecholamines in the anterior hypothalamic area. A fall of blood pressure elicited by the intravenous injection of nitroprusside or chlorisondamine decreased the release of the catecholamines in this hypothalamic area. The changes in blood pressure coincided with the changes in the rates of release of the catecholamines in the anterior hypothalamic area. These and previous results concerning changes in the release of endogenous catecholamines in the posterior hypothalamic nucleus also indicate that in the conscious, freely moving rabbit changes in blood pressure lead to counteracting alterations in the release of catecholamines in the two hypothalamic regions.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00500766
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Artikel (Nationallizenzen)
    Volltext
  • 3
    Digitale Medien
    Digitale Medien
    In vivo release by histamine agonists and antagonists of endogenous catecholamines in the cat hypothalamus (1984)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 326 (1984), S. 116-123 
    Details
    ISSN: 1432-1912
    Schlagwort(e): Hypothalamus ; Push-pull cannula ; Catecholamines ; Histamine ; Histamine receptor agonists ; Histamine receptor antagonists
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The posterior hypothalamus of anaesthetized cats was superfused through a push-pull cannula with histamine agonists and antagonists and the release of endogenous catecholamines was determined in the superfusate. Hypothalamic superfusion with histamine, 2-methylhistamine (H1-agonist), dimaprit (H2-agonist) or metiamide (H2-antagonist) enhanced the release of the catecholamines dopamine, noradrenaline and adrenaline. The releasing effects of these substances depended on the presence of calcium ions. Superfusion with 2-pyridylethylamine (H1-agonist) was virtually ineffective, while superfusion with 2-thiazolethylamine (H1-agonist) enhanced the rate of release of noradrenaline and adrenaline without influencing the release of dopamine. Superfusion with mepyramine (H1-antagonist) inhibited the release of noradrenaline and adrenaline without affecting the release of dopamine. Hypothalamic superfusion with a concentration of procaine which was equi-anaesthetic to that of mepyramine was ineffective. Ranitidine (H2-antagonist) did not alter the rates of release of the catecholamines. The releasing effect of histamine was inhibited on hypothalamic superfusion with mepyramine and ranitidine. Ranitidine also inhibited the releasing effects of dimaprit and 2-methylhistamine thus indicating that the releasing action of the latter compound was mainly due to stimulation of H2-receptors. These data suggest that blockade of H1-receptors of the posterior hypothalamus reduces the release of noradrenaline and adrenaline, while stimulation of H1-receptors seems to increase the rates of release of these two catecholamines. Stimulation of H2-receptors enhances the release of all three catecholamines. Thus, dopaminergic neurones of the hypothalamus seem to possess H2-receptors, while noradrenergic and adrenergic neurones possess H1- and H2-receptors.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00517307
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Artikel (Nationallizenzen)
    Volltext
  • 4
    Digitale Medien
    Digitale Medien
    In vivo release of endogenous catecholamines in the hypothalamus (1979)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 308 (1979), S. 137-142 
    Details
    ISSN: 1432-1912
    Schlagwort(e): Hypothalamus ; Superfusion ; Catecholamine release ; Electrical stimulation ; Locus coeruleus
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The posterior hypothalamus of anaesthetized cats was superfused with a push-pull cannula and the release of the endogenous catecholamines noradrenaline, adrenaline and dopamine was determined in the superfusate. The rate of release of the three catecholamines followed an ultradian rhythm, the time interval between two adjacent phases of high rate of release being about 70 min. Pretreatment of the animals with reserpine decreased the levels of catecholamines in the hypothalamus and rest of the brain and reduced their rate of release into the superfusate. Hypothalamic superfusion with superfusing fluid of high concentration of potassium and low concentration of sodium enhanced the rate of release of noradrenaline and adrenaline; this effect was abolished when the hypothalamus was superfused with calcium-free solution. Electrical stimulation of the locus coeruleus ipsilateral to the superfused hypothalamus increased the release of noradrenaline and adrenaline, stimulation of the contralateral locus coeruleus enhanced the release of noradrenaline, adrenaline and dopamine. In both cases, the rate of release of adrenaline was enhanced to a lesser extent than the rate of release of noradrenaline. The release of noradrenaline and adrenaline was increased to a higher extent on stimulation of the ipsilateral locus coeruleus than on stimulation of the contralateral one.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00499055
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Artikel (Nationallizenzen)
    Volltext
  • 5
    Digitale Medien
    Digitale Medien
    Ein Grenzzonenphänomen an der Haut im Badewannenwasser liegender Leichen (1989)
    Springer
    International journal of legal medicine 102 (1989), S. 473-486 
    Details
    ISSN: 1437-1596
    Schlagwort(e): Bathtub death, skin mark ; Phase transition phenomenon on the skin in waterfilled bathtubs ; Badewannentod, Hautmarke ; Grenzzonenphänomen an der Haut im Badewannenwasser
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin , Rechtswissenschaft
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung In drei Fällen wird ein an Leichen, die nach längerer Liegedauer in wassergefüllten Badewannen aufgefunden wurden, beobachtetes, parallel zur Wasseroberfläche verlaufendes und bis zu etwa 1 cm breites Hauptphänomen berichtet. Im Gegensatz zur umgebenden Haut zeichnet sich die streifenförmige Marke durch Blässe und deutlich geringer ausgeprägte postmortale Veränderungen wie Fäulnis aus. Zur Abklärung wurden an einem Modellfall Temperaturmessungen durchgeführt. Die Ergebnisse lassen die streifige Hautabblassung als thermisches Grenzzonenphänomen erklären. Dieses besitzt auch eine forensische Wertigkeit: das Zeichen bezeugt ein längeres Verweilen des Leichnams in der entsprechenden Lage, bietet eine Aussage betreffend die Höhe des Wasserspiegels und gestattet eine Rekonstruktion der ursprünglichen Position nach Lageveränderung, ist aber kein Vitalitätszeichen.
    Notizen: Summary In three cases a phenomenon is reported, seen on the skin of bodies found dead after a longer time of lying in bathtubs filled with water. The sign was parallel to the surface of the water and showed a breadth up to about 1 cm. Contrary to the surrounding skin, the mark was characterized by paleness and clearly less distinct formation of postmortem alterations as putrefaction. Searching for an explanation, temperature measurements were performed in model. The results showed the marginal paleness of the skin to be a thermal phase transition phenomenon. This mark has a forensic message too: it demonstrates a longer remaining of the corpse in the corresponding position, is a statement concerning the high of the water level, and allows a reconstruction of the original situation after manipulation, but is no sign of vital reaction.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00204078
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Artikel (Nationallizenzen)
    Volltext
Schließen ⊗
Diese Webseite nutzt Cookies und das Analyse-Tool Matomo. Weitere Informationen finden Sie hier...