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  • 1
    Electronic Resource
    Electronic Resource
    Anticonvulsant and cardiovascular effects of substituted thiazolidones (1973)
    s.l. : American Chemical Society
    Journal of medicinal chemistry 16 (1973), S. 178-180 
    Details
    ISSN: 1520-4804
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jm00260a027
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    Paper (German National Licenses)
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  • 2
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    Population Growth and Balance in Economic Development (1959)
    Chicago : Periodicals Archive Online (PAO)
    Economic development and cultural change. 7:3 (1959:Apr.) 206 
    Details
    ISSN: 0013-0079
    Topics: Geography , Economics
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:5112-1959-007-03-000003
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  • 3
    Electronic Resource
    Electronic Resource
    Rise in blood pressure increases the release of endogenous catecholamines in the anterior hypothalamus of the cat (1980)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 310 (1980), S. 237-240 
    Details
    ISSN: 1432-1912
    Keywords: Hypothalamus ; Arterial Blood Pressure ; Catecholamines ; Splanchnic Nerve ; Rise in Blood Pressure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In anaesthetized cats, anterior and posterior hypothalamic areas were simultaneously superfused with artificial CSF using two push-pull cannulae. The rates of release of endogenous catecholamines were determined in the superfusates which were continuously collected in periods of 10 seconds. In both areas, the rate of release of dopamine was higher than the rates of release of noradrenaline and adrenaline. Electrical stimulation of the splanchnic nerve elicited a rise in the arterial blood pressure and increased the rates of release of noradrenaline, adrenaline and dopamine in the anterior hypothalamic area. The rates of release of the catecholamines in the posterior hypothalamic area were not influenced by the pressor response to stimulation of the splanchnic nerve. Transection of the brain caudal to the hypothalamus reduced the rates of release of the catecholamines in the anterior hypothalamus and abolished the releasing effect of the stimulation of the splanchnic nerve. The results indicate that acute rise in blood pressure activates catecholamine cell bodies in the lower brain stem, which in turn stimulate the anterior hypothalamus to counteract the pressor response.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00499916
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  • 4
    Electronic Resource
    Electronic Resource
    Involvement of α1adrenoceptors of nucleus tractus solitarius in baroreflex mediated bradycardia (1982)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 321 (1982), S. 38-43 
    Details
    ISSN: 1432-1912
    Keywords: Baroreflex ; α1Adrenoceptors ; Nucleus tractus solitarius ; Clonidine ; Noradrenaline
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Microinjections of noradrenaline and clonidine into nucleus tractus solitarius produced dose dependent bradycardia without significant decrease in blood pressure in chloralose anaesthetized cats. Phenylephrine failed to produce any significant alteration of heart rate or blood pressure. Piperoxan microinjection into nucleus tractus solitarius elicited a mild but significant tachycardia and could also block the noradrenaline and clonidine responses. Phenoxybenzamine however neither affected resting heart rate and blood pressure nor antagonized the responses of noradrenaline and clonidine. Guanethidine pretreatment of nucleus tractus solitarius also abolished the clonidine response. Baroreceptor reflex activation induced bradycardia was inhibited by yohimbine or piperoxane injected into the cisterna magna or microinjected bilaterally into the nucleus tractus solitarius. Pretreatment of nucleus tractus solitarius with phenoxybenzamine by either route, did not affect the reflex bradycardia. It is concluded that the α-adrenoceptors of nucleus tractus solitarius involved in the decrease in heart rate during baroreceptor activation are α1 in nature.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00586346
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  • 5
    Electronic Resource
    Electronic Resource
    Opioid and non-opioid central cardiovascular effects of ketamine (1990)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 342 (1990), S. 535-538 
    Details
    ISSN: 1432-1912
    Keywords: Blood pressure ; Heart rate ; Ketamine ; Opioid receptor ; Sigma receptor ; Haloperidol ; Phencyclidine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The cardiovascular responses to ketamine injected intracisternally were examined in chloralose anaesthetized cats. Blood pressure and heart rate were recorded at different time intervals after intracisternal injection of drug or saline vehicle. The low doses of ketamine (0.5 or 1.0 mg) elicited dose dependent increase in blood pressure and heart rate. In contrast the high dose of ketamine (4 mg), produced a fall in blood pressure and heart rate. The cardiovascular response elicited by the low dose was naloxone insensitive and completely blocked by haloperidol, but not by dopamine antagonist pimozide. The vasodepressor and bradycardiac effect of the 4 mg dose was naloxone antagonizable. These data show that excitatory cardiovascular effects of the low dose result from a naloxone resistant site while in high doses an inhibitory effect is elicited by action at naloxone sensitive opiate receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00169042
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  • 6
    Electronic Resource
    Electronic Resource
    Nucleus locus coeruleus: Evidence for α1-adrenoceptor mediated hypotension in the cat (1984)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 326 (1984), S. 193-197 
    Details
    ISSN: 1432-1912
    Keywords: α1-Adrenoceptors ; Locus coeruleus ; Clonidine ; Noradrenaline ; Phenylephrine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Microinjection of noradrenaline or phenylephrine into the nucleus locus coeruleus of cats induced a dose dependent and long lasting hypotension. Clonidine was required in a dose of 1 μg for eliciting a significant hypotension while its lower doses (up to 500 ng) failed to elicit any significant cardiovascular alteration. The effects on heart rate evoked by these agents were insignificant. Microinjection of α-adrenoceptor antagonists prazosin, piperoxan and RX 781094 per se did not evoke any significant cardiovascular effects and only prazosin pretreatment showed dose dependent antagonism of the hypotensivee effect of clonidine. Piperoxan was required in four times higher dose (20 μg) to partially antagonize the clonidine induced hypotension. RX 781094, a selective α2-adrenoceptor antagonist, however, even up to a dose of 20 μg (four times that of prazosin) did not alter the effect of clonidine. Similar pattern of antagonism was also seen for noradrenaline and phenylephrine. The results demonstrate the presence of α1-adrenoceptors in the nucleus locus coeruleus, the activation of which leads to a fall in blood pressure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00505317
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  • 7
    Electronic Resource
    Electronic Resource
    Evidence for involvement of α 2Adreonceptors in the nucleus ambiguus in baroreflex-mediated bradycardia (1983)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 323 (1983), S. 199-204 
    Details
    ISSN: 1432-1912
    Keywords: Baroreflex ; α2-Adrenoceptors ; Nucleus ambiguus ; Clonidme ; Noradrenaline
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Microinjection of noradrenaline and clonidine into the nucleus ambiguus elicited dose-dependent bradycardia with insignificant alteration of blood pressure. Phenylephrine failed to elicit any cardiovascular effect. The bradycardic effects of noradrenaline and clonidine were antagonized by piperoxan but not by phenoxybenzamine. Adrenergic neurone blockade with local guanethidine pretreatment also abolished the response to clonidine. No significant cardiovascular effect of clonidine microinjection into the nucleus ambiguus was observed in bilaterally vagotomized animals. The baroreflex bradycardia induced by volume loading was abolished by yohimbine and piperoxan by volume loading was abolished by yohimbine and piperoxan but not by phenoxybenzamine, microinjected bilaterally into the nucleus ambiguus. These results demonstrate the presence of cardioinhihibitory, presynaptic α2-adrenoceptors in the nucleus ambiguus and their involvement in baroreflex bradycardia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00497663
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  • 8
    Electronic Resource
    Electronic Resource
    An analysis of theα-adrenoceptor modulation of vasomotor tone at the level of lateral medullary pressor area (LMPA) (1985)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 330 (1985), S. 163-168 
    Details
    ISSN: 1432-1912
    Keywords: α-Adrenoceptors ; Baroreflex ; Clonidine ; Noradrenaline ; Sympathetic tone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Microinjection of noradrenaline and clonidine into lateral medullary pressor area (LMPA) of chloralose anaesthetized cats produced dose dependent decrease in blood pressure without affecting heart rate, while phenylephrine did not elicit any cardiovascular response. Selectiveα 2-adrenoceptor, antagonists idazoxan and piperoxan, microinjected locally, blocked the effects of the agonists but prazosin and phenoxybenzamine, which are relatively selective forα 1-adrenoceptors, failed to do so. Clonidine did not elicit any response in guanethidine pretreated cats but noradrenaline microinjected into LMPA of these animals induced a pressor response which was blocked by prazosin pretreatment. It is concluded that catecholaminergic fibres impinging upon this are inhibit the activity of the inhibitory second order baroreceptor neurone by activatingα 1-adrenoceptors whileα 2-adrenoceptors situated presynaptically on these inhibitory catecholaminergic nerve terminals are responsible for the manifestation of the hypotensive effect of clonidine and exogenously administered noradrenaline.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00572428
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  • 9
    Electronic Resource
    Electronic Resource
    In vivo release of endogenous catecholamines in the hypothalamus (1979)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 308 (1979), S. 137-142 
    Details
    ISSN: 1432-1912
    Keywords: Hypothalamus ; Superfusion ; Catecholamine release ; Electrical stimulation ; Locus coeruleus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The posterior hypothalamus of anaesthetized cats was superfused with a push-pull cannula and the release of the endogenous catecholamines noradrenaline, adrenaline and dopamine was determined in the superfusate. The rate of release of the three catecholamines followed an ultradian rhythm, the time interval between two adjacent phases of high rate of release being about 70 min. Pretreatment of the animals with reserpine decreased the levels of catecholamines in the hypothalamus and rest of the brain and reduced their rate of release into the superfusate. Hypothalamic superfusion with superfusing fluid of high concentration of potassium and low concentration of sodium enhanced the rate of release of noradrenaline and adrenaline; this effect was abolished when the hypothalamus was superfused with calcium-free solution. Electrical stimulation of the locus coeruleus ipsilateral to the superfused hypothalamus increased the release of noradrenaline and adrenaline, stimulation of the contralateral locus coeruleus enhanced the release of noradrenaline, adrenaline and dopamine. In both cases, the rate of release of adrenaline was enhanced to a lesser extent than the rate of release of noradrenaline. The release of noradrenaline and adrenaline was increased to a higher extent on stimulation of the ipsilateral locus coeruleus than on stimulation of the contralateral one.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00499055
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  • 10
    Electronic Resource
    Electronic Resource
    Involvement of central cholinoceptors in metrazol-induced convulsions (1979)
    Springer
    Psychopharmacology 65 (1979), S. 215-217 
    Details
    ISSN: 1432-2072
    Keywords: Metrazol convulsions ; Central muscarinic ; Cholinoceptors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Atropine sulphate (10 mg/kg IP) afforded 90% protection against clonic convulsions induced by standard doses of metrazol (80 mg/kg SC) in mice, whereas atropine methonitrate (10 mg/kg IP) did not offer any protection. Furthermore, physostigmine (1 mg/kg IP) caused recurrence of convulsions in atropinzed metrazol-treated mice and converted the subconvulsive dose of metrazol (40 mg/kg SC) into a 100% convulsive dose. However, neostigmine (1 mg/kg IP) did not antagonize the protection afforded by atropine sulphate against metrazol. The results of the study suggest an involvement of central cholinergic mechanisms in metrazol-induced convulsions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00433052
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