ISSN:
1432-2072
Keywords:
Metrazol convulsions
;
Central muscarinic
;
Cholinoceptors
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Atropine sulphate (10 mg/kg IP) afforded 90% protection against clonic convulsions induced by standard doses of metrazol (80 mg/kg SC) in mice, whereas atropine methonitrate (10 mg/kg IP) did not offer any protection. Furthermore, physostigmine (1 mg/kg IP) caused recurrence of convulsions in atropinzed metrazol-treated mice and converted the subconvulsive dose of metrazol (40 mg/kg SC) into a 100% convulsive dose. However, neostigmine (1 mg/kg IP) did not antagonize the protection afforded by atropine sulphate against metrazol. The results of the study suggest an involvement of central cholinergic mechanisms in metrazol-induced convulsions.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00433052
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