ISSN:
1432-5233
Schlagwort(e):
Rat Islets
;
Transplantation
;
Bioartificial Pancreas
;
Microencapsulation
;
Insulin Secretion
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Medizin
Notizen:
Abstract Immuno-isolated transplantation offers the attractive prospect of being able to transplant xenogeneic islets without immunosuppression. This study introduces a completely new method of coating single islets using a homogenous alginate membrane approximately 10 μm thick. During glucose challenge (perifusion and static incubation) encapsulated islets show the same pattern and quantity of insulin release as non-encapsulated controls. This encapsulation method markedly reduces the amount of transplanted material by reducing the size of the capsule. It is suggested that encapsulated islets may be transplanted into sites such as the renal capsule or omentum or even by intraportal injection into the liver.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF00572829
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