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  • 1
    Electronic Resource
    Electronic Resource
    Relation of clinical activity of rheumatoid arthritis to immune complexes, complement components and anti-immunoglobulins (1984)
    Springer
    Rheumatology international 4 (1984), S. 159-163 
    Details
    ISSN: 1437-160X
    Keywords: Rheumatoid arthritis ; Immune complexes ; Anti-immunoglobulin ; Complement
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Circulating immune complexes by fluid phase Clq binding assay, complement components and anti-immunoglobulin levels were studied in sera of 35 patients with rheumatoid arthritis (RA). In 23 of the 35 sera (65.7%), circulating immune complexes were positive, and the mean±SD of Clq binding activity (ClqBA), 44.5±19.4%, was significantly high compared to that of healthy persons, 17.4±8.2%. Antigenic determination of complement components revealed that Clq, C3, C5, C9, factor B and Cl esterase inhibitor (CIINH) were significantly high in sera of RA, but C4 and properdin were not. The disease activity correlated with ClqBA, IgG- and IgM-anti-immunoglobulins, C9 and serum IgG. On the other hand, ClqBA correlated with both IgG- and IgM-anti-immunoglobulin levels but not with complement components.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00541207
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Experimental model of disseminated intravascular coagulation induced by sustained infusion of endotoxin (1981)
    Springer
    Research in experimental medicine 179 (1981), S. 223-228 
    Details
    ISSN: 1433-8580
    Keywords: Disseminated intravascular coagulation (DIC) ; Endotoxin ; Rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Experimental disseminated intravascular coagulation (DIC) was induced by sustained infusion of endotoxin into the femoral vein in rats. The severity of DIC was determined with reference to various parameters, such as fibrinogen and fibrin degradation products (FDP), prothrombin time (PT), partial thromboplastin time (PTT), platelet count, and number of renal glomeruli having fibrin thrombi. Experimental DIC could be induced by a 4-h sustained infusion of endotoxin in a dose of 100 mg/kg. The DIC induced in rats showed a close resemblance to human DIC as judged from such changes as an elevation in FDP, prolongation of PT and PTT, depression in fibrinogen and platelet count, and increase in glomeruli having fibrin thrombi. This experimental model has an advantage in that the severity of DIC can be determined by measuring various parameters. It will be of use in the studies aimed at the establishment of a therapy for DIC as well as in the studies on DIC in rats.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01851619
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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