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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Anatomy and embryology 127 (1968), S. 165-174 
    ISSN: 1432-0568
    Keywords: Intramitochondrial Granules ; Mitochondria ; Electron Microscopic Demonstration of Sodium Ions by Komnick's Method ; Proximal Convoluted Tubules (Kidney) ; Bilateral Adrenalectomy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 1. Die Granula intramitochondrialia im distalen Abschnitt der Hauptstücke der Meerschweinchenniere sind je nach der Art der verwendeten Fixierung verschieden groß (Abb. 1–3). Die Fixierung nach Caulfield stellt sie am größten dar (Abb. 1). 2. Weist man die Natriumionen im Gewebe mit der Methode von Komnick nach, so sind die Granula größer und stark elektronendicht (Abb. 5 und 6). 3. Die Natriumverarmung von Meerschweinchen nach bilateraler Adrenalektomie führt zu einer Aufhellung der Granula. Dadurch wird in ihnen ein “Gerüst” sichtbar, das aus trilaminaren Strukturen von der Beschaffenheit der “unit membrane” besteht, welche in der Peripherie der kugeligen Granula intramitochondrialia angeordnet sind (Abb. 7).
    Notes: Summary 1. The size of intramitochondrial granules in the distal portion of the proximal convoluted tubules in the kidney of guinea pigs depends considerably on the method of fixation (Figs. 1–3). Using Caulfield's technique, the granules are particularly large (Fig. 1). 2. The granules are larger and highly adielectronic after the presence of sodium ions has been demonstrated in the tissue according to Komnick's method (Figs. 5 and 6). 3. Following bilateral adrenalectomy in guinea pigs, the sodium loss leads to a clearing of the intramitochondrial granules. Thereby, a system of trilaminar structures of unit membrane type becomes visible (Fig. 7).
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-2013
    Keywords: Two-Kidney-Goldblatt Hypertension ; Renin Containing Granules ; Epitheloid Cells of Afferent Arterioles ; Morphology of Formation of Secretory Granules ; Hyporeninemia ; Renal Cortical Renin ; Plasma Renin Activity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Renal cortical and plasma renin activities and the electron microscopic appearance of juxtaglomerular epitheloid cells were investigated in the unclamped renin-depleted kidney of rats with two-kidney-Goldblatt hypertension after removal of the clamped kidney. Within 24 h the renal renin content fell to still lower values, on the 2d day, it rose to one half its normal value, on the 7th day it reached its control value. Renin activity of plasma did not significantly differ from zero until the 3d day after removing the clamped kidney, reached 20% of normal on the 7th day and normal values between the 7th and the 21 st day. Sparse secretory granules appeared in the remaining renal cortex 12 h after removal of the clamped kidney. After 24 h secretory granules were formed by confluence of Golgi vesicles. After 2 days cisternae appeared in the rough-surfaced endoplasmic reticulum. After 4 days the electron-microscopic picture became normal. Renin appears to be elaborated in the rough-surfaced endoplasmic reticulum and concentrated into granules by the Golgi-apparatus. A fraction of the renal renin does not appear to be available for secretion.
    Type of Medium: Electronic Resource
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