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  • 1
    Electronic Resource
    Electronic Resource
    Increased renal scarring by bacteria with mannose-sensitive pili (1990)
    Springer
    Urological research 18 (1990), S. 299-303 
    Details
    ISSN: 1434-0879
    Keywords: MS pili ; Serratia marcescens ; Renal scarring
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Renal scars are thought to be the end stage of chronic pyelonephritis and one of the most important causes of renal insufficiency and renal hypertension. The role of bacterial pili was examined in scar formation after an infection of newly constructed bacterial strains using the recombinant DNA technique, which possessed either mannose resistant (MR) or mannose sensitive (MS) pili of Serratia marcescens. Strains that differed in only a single virulence factor, namely, MR or MS pili, were used in a rat model of chronic pyelonephritis. In this model, MS-piliated bacteria stimulated renal scarring more severely than non-piliated or MR-piliated bacteria.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00300774
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Role of superoxide in renal scarring following infection by mannose-sensitive piliated bacteria (1991)
    Springer
    Urological research 19 (1991), S. 229-233 
    Details
    ISSN: 1434-0879
    Keywords: Pyelonephritis ; Renal scarring ; Pathogenesis ; Serratia marcescens ; Piliation ; Superoxide dismutase ; Leukocytes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The role of superoxide in scar formation following renal infection caused by mannose-sensitive (MS) piliated strains of bacteria was studied in the experimental pyelonephritis model using female Sprague-Dawley rats. The MS piliated strain stimulated renal scarring to a significantly greater extent than either the non-piliated or MR-piliated strain. Modulation of leukocytes by administering cyclophosphamide to induce neutropenia and colchicine to inhibit leukocyte migration was effective in preventing renal scarring. Treatment with superoxide dismutase during the early stage of infection was also effective in preventing scar formation. Finally, the production of superoxide by rat leukocytes was significantly larger following stimulation by MS piliated than either the nonpiliated or MR piliated strains. These observations suggest that superoxide released from leukocytes plays a critical role in the development of renal scarring following a bacterial infection, especially by MS piliated strains.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00305300
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Effect of prednisolone on ascending renal infection due to biofilm disease and lower urinary tract obstruction in rats (1995)
    Springer
    Urological research 22 (1995), S. 383-387 
    Details
    ISSN: 1434-0879
    Keywords: Lower urinary tract obstruction ; Biofilm disease ; Renal scarring ; Prednisolone ; Ciprofloxacin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A model of renal infection due to lower urinary tract obstruction and biofilm disease was constructed for the study of renal scarring by inserting glass beads coated with bacterial biofilm into the bladder of rats and then clamping the urethra. We previously reported the effect of antimicrobial therapy used in combination with the anti-inflammatory agent prednisolone to prevent renal scarring. In this study we investigated the effect of prednisolone on renal scar formation using our new model. Renal scarring could not be prevented in the group in which prednisolone was administered in the period during which the urethra was regularly being clamped. In contrast, scarring was prevented in the group that began to receive prednisolone after the period of clamping had ended. Therefore, in cases of lower urinary tract obstruction prednisolone should only be administered for the prevention of renal scarrring after the obstruction has been resolved.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00296880
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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