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  • Respiratory distress syndrome  (2)
  • multipoint boundary-value problems  (2)
  • Cyclic AMP synthesis  (1)
  • 1
    Digitale Medien
    Digitale Medien
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/General Subjects 678 (1981), S. 122-131 
    ISSN: 0304-4165
    Schlagwort(e): (Mouse epidermis) ; Cyclic AMP synthesis ; Desensitization ; Isoproterenol stimulation
    Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Thema: Biologie , Chemie und Pharmazie , Medizin , Physik
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Springer
    European journal of pediatrics 135 (1981), S. 245-253 
    ISSN: 1432-1076
    Schlagwort(e): Transient hypothyroidism ; Prophylactic thyroid hormone substitution ; Neonatal intensive care ; Preterm infants ; Respiratory distress syndrome
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Our previous examinations had shown that 9 of 13 premature infants with severe respiratory distress had hypothyroid T4-values. On the basis of these results a prospective study was initiated. Every second neonate born after less than 37 weeks gestation or weighing less than 2200 g and admitted to our intensive care unit since Janary 1979 received a prophylactic dose of 25 μg l-Thyroxine and 5 μg Tri-iodothyronine daily. Five of the patients inadvertently did not receive the drug and were included in the non-treated group which thus numbered 55. Both groups were nearly identical with regard to gestational age, birth weight and Apgar score. In the treated group of 45 infants three (=6.6%) died. In the untreated group of 55 infants 16 (=29%) died. The probability that the different mortality in the two groups was due to chance alone is less than 0.5% (χ2-test: P〈0.005). In 14 of the 55 non-treated patients transient hypothyroidism developed. Five patients with transient hypothyroidism and 2 patients with low T4-values without a TSH-increase were treated with thyroid hormone after ascertainment of their serum thyroxine levels and six survived. The analysis of the prophylactically treated cases showed that the dosage of 25 μg l-Thyroxine and 5 μg Tri-iodothyronine in critically ill infants (i.e., those who were mechanically ventilated or had sepsis) was rarely sufficient to produce normal serum thyroxine levels. In these children thyroxine usually rose to normal levels only when they had passed the acute stage of the disease. It therefore seems advisable to double the dose of thyroid hormone during the acute stage of the disease.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Springer
    European journal of pediatrics 132 (1979), S. 85-92 
    ISSN: 1432-1076
    Schlagwort(e): Transient hypothyroidism ; Neonatal intensive care ; Preterm infants ; Respiratory distress syndrome
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Serial TSH and T4 determinations were performed in sixty neonates admitted to our hospital for neonatal intensive care within a period of three months. Seven patients (12%) showed transient hypothyroidism on the basis of low T4 and high TSH values. Only one of these patients, who had meconium aspiration and pneumonia, did not have the respiratory distress syndrome. In addition, 4 of these patients had sepsis. All of the patients were born before 37 gestational weeks and had birth weight under 2200 g. In addition, two patients of this gestational age and birth weight group had a progressive fall of T4 to extremely hypothyroid values without simultaneous elevation of TSH. Two of the 5 patients who died had histological studies of their thyroids. These revealed colloid-depleted vesicles, desquamated epithelium, and prominent vascularisation of the thyroid. The results of this study show that early recognition and therapy of transient hypothyroidism may be live saving.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 4
    Digitale Medien
    Digitale Medien
    Springer
    Journal of optimization theory and applications 78 (1993), S. 443-463 
    ISSN: 1573-2878
    Schlagwort(e): Differential games ; pursuit-evasion games ; open-loop strategies ; multiple shooting ; multipoint boundary-value problems ; saddle-point trajectories ; barrier trajectories ; missile firing range
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Mathematik
    Notizen: Abstract In Part 1 of this paper (Ref. 1), necessary conditions for optimal open-loop strategies in differential games of pursuit-evasion type have been developed for problems which involve state variable inequality constraints and nonsmooth data. These necessary conditions lead to multipoint boundary-value problems with jump conditions. These problems can be solved very efficiently and accurately by the well-known multiple-shooting method. By this approach, optimal open-loop strategies and their associated saddle-point trajectories can be computed for the entire capture zone of the game. This also includes the computation of optimal open-loop strategies and saddle-point trajectories on the barrier of the pursuit-evasion game. The open-loop strategies provide an open-loop representation of the optimal feedback strategies. Numerical results are obtained for a special air combat scenario between one medium-range air-to-air missile and one high-performance aircraft in a vertical plane. A dynamic pressure limit for the aircraft imposes a state variable inequality constraint of the first order. Special emphasis is laid on realistic approximations of the lift, drag, and thrust of both vehicles and the atmospheric data. In particular, saddle-point trajectories on the barrier are computed and discussed. Submanifolds of the barrier which separate the initial values of the capture zone from those of the escape zone are computed for two representative launch positions of the missible. By this way, the firing range of the pursuing missile is determined and visualized.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 5
    Digitale Medien
    Digitale Medien
    Springer
    Journal of optimization theory and applications 78 (1993), S. 419-441 
    ISSN: 1573-2878
    Schlagwort(e): Differential games ; pursuit-evasion games ; singular surfaces ; barrier surface ; state constraints ; open-loop strategies ; multipoint boundary-value problems ; flight mechanics ; missile firing range
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Mathematik
    Notizen: Abstract Complex pursuit-evasion games with state variable inequality constraints are investigated. Necessary conditions of the first and the second order for optimal trajectories are developed, which enable the calculation of optimal open-loop strategies. The necessary conditions on singular surfaces induced by state constraints and non-smooth data are discussed in detail. These conditions lead to multi-point boundary-value problems which can be solved very efficiently and very accurately by the multiple shooting method. A realistically modelled pursuit-evasion problem for one air-to-air missile versus one high performance aircraft in a vertical plane serves as an example. For this pursuit-evasion game, the barrier surface is investigated, which determines the firing range of the missile. The numerical method for solving this problem and extensive numerical results will be presented and discussed in Part 2 of this paper; see Ref. 1.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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