ISSN:
1432-0533
Keywords:
Neuroblastoma
;
Differentiation
;
Retinoic acid
;
Proto-oncogene
;
Tyrosine phosphorylation
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Four human neuroblastoma cell lines exhibited differences in their ability to differentiate into neuron-like cells in response to three different treatments, serum deprivation, or additions of dibutyryl cyclic-AMP or retinoic acid. Expression of N-myc gene product was reduced in neuroblastoma cell line SK-N-DZ differentiated by retinoic acid as compared with untreated cells. On the contrary, expression of c-src gene product, pp60c-src, was considerably enhanced in differentiated SK-N-DZ cells. Tyrosine phosphorylation of several cellular proteins was found to be enhanced in differentiated cells. Alteration in expression of these proto-oncogene products might be important in the differentiation of neuroblastoma cells into neuron-like cells.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00294382
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