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  • Quantification  (1)
  • Reversed-phase, ion-pair liquid chromatography  (1)
  • 1
    Digitale Medien
    Digitale Medien
    Stability study and quantitative determination of mebeverine hydrochloride in tablets by means of reversed-phase high-performance liquid chromatography (1985)
    Springer
    Chromatographia 20 (1985), S. 185-192 
    Details
    ISSN: 1612-1112
    Schlagwort(e): Reversed-phase HPLC ; Quantification ; Mebeverine hydrochloride ; Stability ; Mass spectrometry
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary A rapid and specific reversed-phase high-performance liquid chromatographic method (RPHPLC) is described for the determination of mebeverine hydrochloride in tablets. Elution was performed on an octyl silane column with a methanol-water mixture (75-25), containing 0.05% hexylamine as silanol-blocking agent, adjusted to pH 5.0 with phosphoric acid. The method gave accurate, precise and reproducible results. The mean recovery of the drug from six synthetic tablet mixtures was 100.0% with a relative standard deviation (RSD) of 0.94%. In order to test the specificity of the method, the interference of the degradation compounds of mebeverine hydrochloride and of the intermediates from the synthesis was investigated. None of them did interfere. By means of mass spectrometry and UV-spectrophotometry, the degradation compounds of mebeverine were identified as veratric acid and as 4-|ethyl-[2-(4-methoxyphenyl)-1-methylethyl]amino| 1-butanol. The stability study proved that mebeverine hydrochloride is very stable in tablets; the tablets still contain more than 95% of the declared drug potency after storage for more than one year at 50°C.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02262709
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  • 2
    Digitale Medien
    Digitale Medien
    Analysis of propantheline bromide and related quaternary ammonium drugs by reversed-phase, ion-pair liquid chromatography with two counterions in the eluent (1987)
    Springer
    Chromatographia 23 (1987), S. 667-674 
    Details
    ISSN: 1612-1112
    Schlagwort(e): Reversed-phase, ion-pair liquid chromatography ; Propantheline bromide ; Methantheline bromide ; Stability ; Retention mechanism
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary The addition of appropriate concentrations of an organic amine and an alkylsulphonate to the mobile phase in reversed-phase, ion-pair liquid chromatography can introduce unique selectivity in to the chromatographic system allowing separation of complex mixtures of basic, acidic and neutral compounds. As an example, the methodology for a specific stability-indicating determination of propantheline bromide, a quaternary ammonium anticholinergic agent, on several reversedphase stationary phases, was developed. The retention mechanism was studied and it was concluded that both ion-interaction processes and ion-exchange processes were involved in the separation technique developed with two counterions of opposite charge in the eluent.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02311497
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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