Electronic Resource
Springer
European archives of oto-rhino-laryngology and head & neck
253 (1996), S. 367-370
ISSN:
1434-4726
Keywords:
Furosemide-induced ototoxicity
;
Scala tympani
;
Oxygen tension
;
Auditory cortical-evoked potentials
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The effects of intravenous furosemide on the perilymphatic oxygen tension of the scala tympani (OT) in the guinea pig and the relationship between changes in OT and changes in auditory cortical-evoked reponses were studied, as well as changes in cochlear morphology. Furosemide in dosages of 25 mg/kg and 50 mg/kg caused a sharp decline in OT in addition to elevation of the threshold of auditory cortical-evoked responses. Ischemia of the cochlear stria vascularis was also found but without any damage of hair cells at the light microscopic level. Changes in OT were associated with transient threshold elevations and ischemia of the stria vascularis. Improvements in hearing were directly proportional to the recovery of OT.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00178294
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