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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European archives of psychiatry and clinical neuroscience 242 (1993), S. 191-196 
    ISSN: 1433-8491
    Keywords: Sleep EEG ; Deterministic Chaos ; Dimensionality ; Schizophrenia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Deterministic chaos could be regarded as a healthy flexibility of the human brain necessary for correct neuronal operations. Several investigations have demonstrated that in healthy subjects the dimensionality of REM sleep is much higher than that of slow wave sleep (SWS). We investigated the sleep-EEG of schizophrenic patients with methods from nonlinear system theory in order to estimate the dynamic properties of CNS. We hypothesized that schizophrenics would reveal alterations of their dynamic EEG features indicating impaired information processing. In 11 schizophrenic patients, the EEG's dimensionality during sleep stages II and REM was reduced. We suggest that such lower dimensional chaotic processes might be associated with an overloading of neuronal networks during sleep and therefore the psychopathology of schizophrenics might be due to impaired complexity of their EEG's dynamics.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1433-0407
    Keywords: Schlüsselwörter Akupunktur ; Depression ; Mianserin ; Placebokontrolliert ; Key words Acupuncture ; Depression ; Mianserine ; Placebo-controlled study
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary In order to examine the efficacy of whole body acupuncture additionally applied to drug treatment in depression, a single-blind placebo-controlled study with 70 inpatients administered to three different treatment groups has been carried out. All patients were pharmacologically treated with the tetracyclic antidepressant mianserin. The verum group (n=22) received acupuncture at specific points considered to be effective in the treatment of depression. The placebo group (n=24) was treated with acupuncture at non-specific locations and the control group (n=24) received only pharmacological treatment. Acupuncture was applied three times a week over a period of four weeks. Psychopathology was rated by judges blind to verum/placebo conditions twice a week over eight weeks with the CGI, GAS, BRMS and BfS rating scales. Additionally applied acupuncture improved the course of depression more than pharmacological treatment with mianserin did by itself. However, we could not detect any differences between placebo and verum acupuncture.
    Notes: Zusammenfassung Um die Wirksamkeit einer begleitenden Ganzkörperakupunktur bei Patienten mit einer Depression zu untersuchen, wurden 70 stationäre Patienten in eine placebokontrollierte Studie eingeschlossen und randomisiert auf 3 Behandlungsgruppen aufgeteilt. Während alle 3 Gruppen pharmakologisch mit dem tetrazyklischen Antidepressivum Mianserin behandelt wurden, erhielt die Verumakupunkturgruppe (n=22) zusätzlich eine Akupunktur an spezifischen Punkten, die als wirksam in der Behandlung einer Depression angesehen werden. Die Placeboakupunkturgruppe (n=24) wurde mit einer Akupunktur an nicht spezifischen Punkten behandelt, und die Kontrollgruppe (n=24) wurde nur mit Mianserin behandelt. Die Akupunktursitzungen fanden dreimal pro Woche über einen Zeitraum von vier aufeinanderfolgenden Wochen statt. Die psychopathologische Symptomatik wurde zweimal pro Woche über einen Zeitraum von acht aufeinanderfolgenden Wochen mittels der Instrumente CGI, GAS, BRMS und BfS beurteilt. Die Besserung des psychopathologischen Befundes von Patienten, die akupunktiert wurden (Verum- und Placeboakupunktur), war signifikant höher als bei Patienten, die mit Mianserin alleine behandelt wurden. Es ergab sich jedoch kein Unterschied zwischen den beiden Akupunkturgruppen.
    Type of Medium: Electronic Resource
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