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  • 1
    Electronic Resource
    Electronic Resource
    Evaluation of a method for measuring the sustainable rate of sebaceous wax ester secretion (1987)
    Springer
    Archives of dermatological research 279 (1987), S. 266-269 
    Details
    ISSN: 1432-069X
    Keywords: Sebum secretion ; Bentonite method ; Thin-layer chromatography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Sebaceous was ester secretion rates were measured in six subjects on six occasions each, using absorption into bentonite clay and analysis of the collected lipid by quantitative thin-layer chromatography. On each occasion eight samples were collected, four from the left and four from the right side of the forehead in four successive intervals. The first two intervals, which totaled 14 h, were intended to deplete the follicular reservoir of sebum so that a constant rate of absorption could be obtained during the third and fourth intervals, which were 3 h each. Thin-layer analysis of each sample was done in triplicate. The data were examined using analysis of variance techniques to determine the reproducibility of the measurement method and to identify possible sources of variability. The intraclass correlation coefficient (r 1) for all 432 post-depletion determinations was 0.80. The reproducibility was considerably better for three of the subjects (r 1=0.93) than for the other three (r 1=0.75). Variability within the latter three subjects did not seem to be attributable to lack of reproducibility in the thinlayer analysis. Real biological variability also seems unlikely considering the holocrine mechanisms of sebum secretion. Therefore, the variability probably arises from non-representative collection of sebum into the bentonite absorbent.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00417326
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of cyproterone acetate-ethinyl estradiol treatment on the proportions of linoleic and sebaleic acids in various skin surface lipid classes (1986)
    Springer
    Archives of dermatological research 278 (1986), S. 481-485 
    Details
    ISSN: 1432-069X
    Keywords: Cyproterone acetate ; Ethinyl estradiol ; Sebum secretion ; Sebum composition ; Linoleic acid ; Acne
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effect of high-dose cyproterone acetateethinyl estradiol treatment on rates of sebum secretion and on the proportions of linoleic acid (18∶2Δ9,12) and sebaleic acid (18∶2Δ5,8) in the skin surface lipids of three female acne patients was examined. Changes in rates of sebum secretion were evaluated indirectly by measuring the ratio of wax esters/(cholesterol +cholesterol esters) in the subjects' skin surface lipid. In two of the subjects, this ratio indicated a reduction of sebum secretion rates to the childhood range. Concomitantly, there was an increase in linoleic acid and a decrease in sebaleic acid in all lipid classes. In the third subject, in whom there was only a small reduction in sebum secretion rate, the proportion of linoleic acid in the cholesterol esters more than doubled, but the changes in the other lipid classes were small or nonexistent. The results indicate that the proportions of linoleic acid and sebaleic acid in sebum are influenced by sebum secretion rates.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00455168
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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