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  • Shoulder  (2)
  • Abduction  (1)
  • B chain  (1)
  • 1
    Digitale Medien
    Digitale Medien
    Homogeneous mono-125I-insulins (1980)
    Springer
    Diabetologia 19 (1980), S. 546-554 
    Details
    ISSN: 1432-0428
    Schlagwort(e): 125I-insulin ; insulin ; radioiodination ; iodate ; lactoperoxidase ; monoiodotyrosine ; diiodotyrosine ; A chain ; B chain ; tyrosine-A14 ; tyrosine-A19 ; insulin immunoassay ; radiochemical purity ; radioimmunochemical stability
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Mono-125I-(Tyr A19)-insulin (Mono *A19) was prepared by iodinating MC porcine insulin with 125I in acid medium using iodate (as oxidizing agent), followed by anion-exchange chromatography. Mono-125I-(Tyr A14)-insulin (Mono *A14) was prepared by iodinating MC porcine insulin with 125I, using H2O2/lactoperoxidase at neutral pH, followed by anion-exchange chromatography. The specific radioactivities were in the ranges of 120–200 and 220–300 mCi/mg for Mono *A19 and Mono *A14, respectively. Analyses of the intramolecular distributions of 125I demonstrated that the preparations were 97–98% radiochemically pure. In both preparations, 98–99% of the radioactivity was capable of binding to insulin antibodies for up to 6 months of storage of the tracers. The IRI concentration decreased with the duration of storage. The greatest observed fall in IRI concentration was 70%. The time course could be explained by the assumption that the disintegration of a 125I-nucleus destroys the immunoreactivity of the insulin molecule in which the decay occurs.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00253183
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  • 2
    Digitale Medien
    Digitale Medien
    Intramuscular laser-Doppler flowmetry in the supraspinatus muscle during isometric contractions (1995)
    Springer
    European journal of applied physiology 71 (1995), S. 373-378 
    Details
    ISSN: 1439-6327
    Schlagwort(e): Microcirculation ; Shoulder ; Abduction ; Laser-Doppler
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract To study the regulation of microvascular blood flow in a compartment muscle, laser-Doppler measurements of muscle microcirculation were recorded in the supraspinatus muscle in eight volunteers during and following submaximal isometric muscle contractions. The subjects performed isometric shoulder abductions at five contraction levels from 5% to 50% maximal voluntary contraction for I min each and a sustained 30° shoulder abduction for 20 min. The subjects' perceived exertion increased from “no perceived exertion” to “near maximal exertion” during the 20-min period with 30° shoulder abduction. Microcirculation increased during all 1-min contractions. Following the contractions at 20%, 30% and 50% MVC post-exercise reactive hyperaemia was seen for a period of at least 1 min. The reactive hyperaemia increased in magnitude in response to increasing contraction level. The results showed the same time-history of the blood flow at microvascular level as previously seen in larger peripheral vessels in response to muscle contractions. During the 20-min contraction microcirculation increased in line with the findings during the brief contractions. However, in contrast to the brief contractions no postexercise reactive hyperaemia occurred following the prolonged contraction. Lack of postexercise reactive hyperaemia following the prolonged shoulder abduction would suggest insufficient regulation of the vascular resistance. Alternatively, lack of hyperaemia could be taken as an indication of sufficient microcirculation during the preceding contraction. From previous studies on intramuscular pressure and metabolism the latter alternative would seem unlikely.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00240420
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  • 3
    Digitale Medien
    Digitale Medien
    The effect of prolonged isometric contractions on muscle fluid balance (1994)
    Springer
    European journal of applied physiology 69 (1994), S. 439-444 
    Details
    ISSN: 1439-6327
    Schlagwort(e): Shoulder ; Isometric contraction ; Ultrasound ; Fluid balance ; Muscle pain
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Ultrasound scanning was performed at three sites above the fossa supraspinata on nine healthy subjects and five patients with myofascial shoulder pain. This method produced a well-defined depiction of the soft tissue layers above the fossa supraspinata and reproducible muscle thickness measurements. In the healthy subjects the average distance from the skin surface to the trapezius muscle was 7.7 mm and the average thickness of the trapezius muscle was 5.3 mm, and the average thickness of supraspinatus muscle was 20.0 mm. The supraspinatus muscle was thinner at the medial measuring site than at the other two sites. In contrast, a tendency towards a larger distance was seen from the skin to trapezius muscle at the medial measuring site than at the other two sites. No statistical differences were found between the two groups of subjects either at rest or during brief shoulder abductions. All the subjects performed a 30° unilateral isometric shoulder abduction test to exhaustion. The median endurance time was 33 min for the healthy subjects and only 5 min for the patients. The ratings of perceived exertion (RPE) were in line with this, since the increment in RPE with time was larger for the patients than for the healthy group. The reduced shoulder abduction endurance time in the patient group may have been related to impaired muscle function and/or pain development. During the 33-min shoulder abduction in the healthy subjects, the thickness of supraspinatus muscle increased by 14%, indicating muscle swelling, whereas the thickness of trapezius muscle remained constant. The fluid imbalance in the supraspinatus muscle compartment may well play a role in the development of muscle fatigue and the disorders found in industry resulting from prolonged work with arms elevated.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00865409
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