ISSN:
1434-0879
Keywords:
Renal interstitial fluid
;
Soft tissue interstitial fluid
;
Antibiotic concentration
;
Pyelonephritis
;
Experimental canine model
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary In a new canine experimental model the time concentration relationship of cephalothin in serum, urine, soft tissue interstitial fluid (STIF) and renal interstitial fluid (RIF) were compared simultaneously. Antibiotic concentration in RIF was less than urinary levels but exceeded the serum concentration. Urinary antibiotic concentration does not necessarily reflect concentration in the renal interstitium. This model helps to understand the basic pharmacokinetics of antibiotics in the renal interstitium where pyelonephritis occurs.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00261952
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