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Digitale Medien

A path-analytical approach to differentiate between direct and indirect drug effects on negative symptoms in schizophrenic patients (1995)

Möller, Hans-Jürgen ; Müller, Horst ; Borison, Richard L. ; [weitere]

Springer

European archives of psychiatry and clinical neuroscience 245 (1995), S. 45-49

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ISSN: 1433-8491

Schlagwort(e): Neuroleptics ; Negative symptoms ; Risperidone ; Schizophrenia ; Haloperidol

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Abstract The hypothesis that differences in drug effects of risperidone and haloperidol on negative symptoms in schizophrenia are secondary to effects on positive, extrapyramidal, and depressive symptoms was investigated by means of an analysis of the data from the USA-Canada risperidone double-blind randomized clinical trial of 523 chronic schizophrenic patients. Regression analyses in the total sample and within treatment groups confirmed a strong relationship between changes in negative symptoms and the other variables studied (R2=0.50−0.51,p〈0.001). Only depressive symptoms did not contribute significantly to these results (p〉0.10). Path analysis showed that the greater mean change (p〈0.05) of negative symptoms with risperidone compared to haloperidol could not be fully explained by correlations with favourable effects on positive and extrapyramidal symptoms. The relationship between shift in extrapyramidal symptoms and shift in negative symptoms failed to reach statistical significance; however, there was a clear tendency in the expected direction in both treatment groups.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF02191543

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Digitale Medien

Chemical Effects of Nuclear Transformations in Solids (1967)

Müller, Horst

Weinheim : Wiley-Blackwell

Angewandte Chemie International Edition in English 6 (1967), S. 133-149

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ISSN: 0570-0833

Schlagwort(e): Solids ; Radiochemistry ; Nuclear chemistry ; Chemistry ; General Chemistry

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: Nuclear reactions and radioactive transformations offer the possibility of investigating the chemical reactions of “bare” nuclei. The interest in such chemical processes following nuclear transformations has already led to two international symposia[1,2]. In solids, the chemical reactions of recoil nuclei having energies lower than 1 keV proceed not via molten states, but via regions of little disorder.

Zusätzliches Material: 9 Ill.