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  • 1
    Electronic Resource
    Electronic Resource
    Low conductance states of a single ion channel are not ‘closed’ (1995)
    Springer
    The journal of membrane biology 147 (1995), S. 233-239 
    Details
    ISSN: 1432-1424
    Keywords: Alpha toxin ; Channel size ; Conductance states ; Planar bilayer ; Polymer exclusion ; Staphylococcus aureus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract We have used a polymer-exclusion method to estimate the sizes of the high and low-conductance states of Staphylococcus aureus α-toxin channels across planar lipid bilayers. Despite a 〉10-fold difference in conductance between high and low-conductance states, the size differs by 〈2-fold. We conclude that factors other than the dimensions have a strong influence on the conductance of α-toxin channels. We also show that the high conductance state is destabilized by the presence of high molecular weight polymers outside the channel, compatible with the removal of channel water as the high conductance state “shrinks” to the low conductance state.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00234521
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Staphylococcus aureus alpha-toxin-induced pores: Channel-like behavior in lipid bilayers and patch clamped cells (1995)
    Springer
    The journal of membrane biology 143 (1995), S. 143-151 
    Details
    ISSN: 1432-1424
    Keywords: Alpha toxin ; Ion channel ; Lettre cell ; Patch clamp ; Planar bilayer ; Staphylococcus aureus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract The conductance of pores induced by Staphylococcus aureus α-toxin in Lettre cells has been compared to that in bilayers composed of synthetic lipids or Lettre cell membrane constituents. Previously described characteristics of toxin-induced conductance changes in lipid bilayers, namely rectification, voltage-dependent closure, and closure at low pH or in the presence of divalent cations (Menestrina, 1986) are displayed also in bilayers prepared from Lettre cell membranes and in patch clamped Lettre cells. It is concluded that endogenous proteins do not affect the properties of α-toxininduced channels significantly and that the relative lack of ion channels in Lettre cells makes them ideal for studies of pore-forming toxins by the patch clamp technique.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00234660
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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