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  • 1
    Electronic Resource
    Electronic Resource
    Tissue engineering of the vascular system: From capillaries to larger blood vessels (2000)
    Springer
    Medical & biological engineering & computing 38 (2000), S. 232-240 
    Details
    ISSN: 1741-0444
    Keywords: Tissue engineering ; Skin ; blood vessel ; Organ models ; Culture ; In vitro
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract Tissue engineering is a novel approach to the repair of wounded tissues. Application of this technology to the vascular system is important because of the fundamental nutritional role of the vasculature. This perspective is currently being applied to the first tissue-engineered organ: the skin. Knowledge of capillary constitution and factors inducing their formation has led to attempts to induce their formation in reconstructed skin. Such vascular conduits grown in vitro could also benefit the nutrition of tissues and organs in vivo. The paper reviews recent progress in thein-vitro development of vascularised skin and tissue-engineered blood vessels. It points out the necessity of obtaining pure and well-characterised cultures of the different cell populations that are the basic building blocks of the reconstructions. The importance of an adequate cell-culture environment (nutrients and bi-or tri-dimensional scaffolds for cells) for success in elaborating a reconstructed living tissue able to replace the original is emphasised. Engineered tissues can serve not only as tissue replacements but also asin-vitro models for research in organ physiology and physiopathology. These tissues are also attractive vehicles for gene therapy, one of the more promising new methods of disease treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02344782
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Cyclic Traction Machine for Long-Term Culture of Fibroblast-Populated Collagen Gels (1999)
    Springer
    Annals of biomedical engineering 27 (1999), S. 67-72 
    Details
    ISSN: 1573-9686
    Keywords: Tissue engineering ; Collagen gels ; Fibroblasts ; Cyclic traction ; Traction machine ; Collagen fibers orientation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: Abstract Our research group has been investigating the effect of cyclic deformations on the evolution of fibroblast populated collagen gels (FPCG). Since existing traction machines are not designed for such an application, we had to design a cyclic traction machine adapted to tissue culture inside an incubator over an extended period of time. Biocompatible materials were used for fabrication to allow for easy sterilization and to prevent any adverse reaction from the tissue. The traction machine is based on a computer-controlled stepping motor system for easy adjustment of the deformation amplitude and frequency. The maximum stretching speed achieved is around 1mm/s. The traction machine can measure FPCG mechanical properties and perform rupture tests to determine its ultimate strength. Several FPCGs have been successfully cultured with the machine for up to four weeks without any adverse reaction. © 1999 Biomedical Engineering Society. PAC99: 8270Gg, 8380Lz
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1114/1.166
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    Paper (German National Licenses)
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