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Digitale Medien

The role of the liver in the clearance ofl-dopa from plasma (1975)

Mearrick, Peter T. ; Graham, Garry G. ; Wade, Denis N.

Springer

Journal of pharmacokinetics and pharmacodynamics 3 (1975), S. 13-23

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ISSN: 1573-8744

Schlagwort(e): l-dopa ; plasma half-life ; plasma clearance ; total body clearance ; hepatic clearance

Quelle: Springer Online Journal Archives 1860-2000

Thema: Chemie und Pharmazie

Notizen: Abstract The role of the liver in the plasma clearance of l-dopa in the rat was examined. Some published studies which ascribe an important role to the liver in l-dopa clearance are discussed and critically evaluated. Contrary evidence suggesting that the liver is not a significant site of l-dopa clearance in vivo ispresented. The plasma concentration of l-dopa during intravenous infusion of the drug was not significantly reduced after a single passage through the liver. All of the data discussed are consistent with the conclusion that the liver plays a minor role in l-dopa clearance in vivo.It is suggested that the small intestine is the major site of metabolism of orally administered l-dopa.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01066592

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Digitale Medien

Syntheses of Zindoxifene and Analogues by Titanium-Induced Oxo-Amide Coupling (1994)

fürstner, Alois ; Jumbam, Denis N. ; Seidel, Günter

Weinheim : Wiley-Blackwell

Berichte der deutschen chemischen Gesellschaft 127 (1994), S. 1125-1130

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ISSN: 0009-2940

Schlagwort(e): Indoles, 2-aryl- ; Titanium graphite ; Zindoxifene ; Tumor-growth inhibitors ; Alkylidenation, intramolecular ; Chemistry ; Inorganic Chemistry

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: Highly reactive titanium on graphite is used to reductively cyclize electron-rich acylamino carbonyl compounds 7, 8, 12, 14, and 16 to the corresponding indole derivatives 9, 10, 13, 15, and 17. Compound 9b is a known precursor of the mammary tumor-inhibiting compound zindoxifene (2). The other products are new analogues of this anticancer drug, exhibiting the substitution pattern previously recognized to be essential for high pharmacological activity.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/cber.19941270624

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