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  • 1
    ISSN: 1432-1335
    Keywords: Autochthonous colonic tumors ; N-nitrosoacetoxymethyl-methylamine ; 1,2-Dimethylhydrazine ; 5-Fluorouracil ; Ftorafur ; CGP 6809 ; CGP 15'720A
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Colonic tumors were induced in male Sprague-Dawley rats by ten applications of 2 mg/kg/week N-nitrosoacetoxymethyl-methylamine (AMMN) or by three applications of 100 mg/kg/month 1,2-dimethylhydrazine (1,2-DMH). Application of AMMN and 1,2-DMH induced selective colonic tumors in 97% and 29–42% of the initial animals, respectively. Colonic-tumor-bearing animals were subjected to monotherapy with 5-fluorouracil, ftorafur, CGP 6809, and CGP 15'720A. No cures were achieved. The different therapies did not exert any clear influence on the survival time of animals, except for animals pretreated with AMMN and then subjected to ftorafur therapy.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 361 (1983), S. 764-765 
    ISSN: 1435-2451
    Keywords: Long-term results ; Total gastrectomy ; Gastrektomie ; Langzeitergebnisse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 1676 Patienten, bei denen nach verschiedenen OP-Verfahren der Magenersatz nach totaler Gastrektomie durchgeführt wurde, wurden auf folgende Parameter untersucht: Reflux, Dumping-Syndrom, Diarrhoe, Gewichtsverlust über 5 kg. Unabhängig von der OP-Art waren Letalität (10–12 %) und Insuffizienzrate (8–12 %) vergleichbar. Folgerungen: 1. Unter den 7 verglichenen OP-Verfahren scheint die Roux-Anastomose unter Berücksichtigung des Risikos eines Refluxes (18%) und des Dumping-Syndroms (18 %) am günstigsten. 2. Die Jejunuminterposition (70 cm Länge) ergibt die besten funktionellen Ergebnisse. 3. Die Wiederherstellung der Reservoirfunktion des Magens ist durch jedes der beschriebenen Verfahren möglich.
    Notes: Summary A total of 1676 patients who had total gastrectomies by different surgical procedures were checked up for the following parameters: reflux, dumping syndrome, diarrhoea, weight loss over 5 kg. We compared the results of seven different procedures. Independent of the surgical technique, operative mortality (10 %–12 %) and rate of leakage (8 %–12 Y.) were comparable. Conclusions: (1) The Roux procedure seems to be the most advantageous as regards reflux (18 %) and dumping syndrome (18 %). (2) Jejunum interposition gives the best functional results. (3) Reconstruction of the reservoir function is possible with the seven procedures described.
    Type of Medium: Electronic Resource
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