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  • 1
    Electronic Resource
    Electronic Resource
    Increased activity of enzymes of the tricarboxylic acid cycle in response to aldosterone in the toad bladder (1968)
    Springer
    Pflügers Archiv 300 (1968), S. 213-225 
    Details
    ISSN: 1432-2013
    Keywords: Biological Transport, active ; Aldosterone ; Sodium ; Enzymes ; Tricarboxylic Acid Cycle ; Aktiver Transport ; Aldosteron ; Natrium ; Enzyme ; Trikarbonsäurecyclus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. The activities of condensing enzyme, isocitrate dehydrogenase, glutamate dehydrogenase, glutamate-oxaloacetate transaminase, and malate dehydrogenase increase in toad bladder mucosa in vitro 2 hours after addition of d-aldosterone (10−7 M) to the serosal bathing medium whereas no change in activity of lactate dehydrogenase, aldolase and pyruvate kinase was noted. 2. The increase in enzyme activities has approximately the same time course as the stimulation of sodium transport by aldosterone. 3. The response of sodium transport to d-aldosterone was studied in the same tissue which was assayed for enzymatic activity. A significant, positive correlation between relative increments in sodium transport and in condensing enzyme activity per milligram of mucosal protein was found to exist. 4. The effects of aldosterone on both sodium transport and enzyme enhancement were abolished by actinomycin D and puromycin. 5. The increase in activity of mitochondrial enzymes due to d-aldosterone was not dependent on the presence of sodium in the mucosal bathing medium and hence was independent of any possible direct stimulatory effect of transepithelial sodium transport on enzyme activity. 6. The increase in activity of enzymes contributing to the supply of aerobic energy for the enhanced sodium transport induced by aldosterone is regarded as complementary to an independent action of the hormone to increase the entry of sodium into the transport process.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00364295
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  • 2
    Electronic Resource
    Electronic Resource
    Der Einfluß von Aldosteron auf die Aktivität mitochondrialer und cytoplasmatischer Enzyme in der Rattenniere (1968)
    Springer
    Pflügers Archiv 300 (1968), S. 244-254 
    Details
    ISSN: 1432-2013
    Keywords: Aldosterone ; Adrenalectomy ; Sodium Transport ; Tricarboxylic Acid Cycle ; Enzyme Activity ; Aldosteron ; Adrenalektomie ; Natriumtransport ; Citronensäurecyclus ; Enzymaktivität
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In Nieren normaler und adrenalektomierter Ratten wurde die Aktivität des condensing enzyme, der TPN-Isocitrat-Dehydrogenase, DPN-Isocitrat-Dehydrogenase, Succinat-Dehydrogenase, Malat-Dehydrogenase, Glutamat-Oxalacetat-Transaminase, Glutamat-Dehydrogenase, β-Hydroxybutyrat-Dehydrogenase, α-Glycerophosphat-Oxydase, Glyceraldehydphosphat-Dehydrogenase, Lactat-Dehydrogenase, Pyruvat-Kinase und des malic enzyme bestimmt. Adrenalektomie bewirkt eine Abnahme der Aktivität des condensing enzyme um 44%, der TPN-Isocitrat-Dehydrogenase um 20%, der Glutamat-Oxalacetat-Transaminase um 23%, der Glutamat-Dehydrogenase um 23% und der Glyceraldehydphosphat-Dehydrogenase um 17%. Gabe von Aldosteron bei adrenalektomierten Tieren normalisiert die Aktivität des condensing enzyme, der TPN-Isocitrat-Dehydrogenase und der Glutamat-Dehydrogenase, die Aktivität der Glutamat-Oxalacetat-Transaminase und der Glyceraldehydphosphat-Dehydrogenase zeigt eine nicht zur Normalisierung ausreichende Steigerung. Außerdem wird die durch Adrenalektomie nicht veränderte Aktivität der Succinat-Dehydrogenase um 10% erhöht.
    Notes: Summary The activity of the following enzymes was determined in kidneys of normal and adrenalectomized rats: condensing enzyme, isocitrate dehydrogenase (NADP and NAD), succinate dehydrogenase, malate dehydrogenase, aspartate aminotransferase, glutamate dehydrogenase, hydroxybutyrate dehydrogenase, glycerophosphat dehydrogenase, glyceraldehydphosphat dehydrogenase, pyruvate kinase, lactate dehydrogenase, malate dehydrogenase (decarboxylating, NADP). Adrenalectomy lowers the activity of condensing enzyme by 44%, of isocitrate dehydrogenase (NADP) by 20%, of aspartate aminotransferase by 23%, of glutamate dehydrogenase by 23% and of glyceraldehydphosphat dehydrogenase by 17%. Aldosterone given to adrenalectomized rats normalises the activity of condensing enzyme, isocitrate dehydrogenase (NADP), and glutamate dehydrogenase, the activity of aspartate aminotransferase and glyceraldehydphosphat dehydrogenase increases without reaching the control levels. The activity of succinate dehydrogenase is not influenced by adrenalectomy but is augmented by aldosterone treatment of adrenalectomized animals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00364297
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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