ISSN:
1432-2218
Schlagwort(e):
Pneumoperitoneum
;
Tumor seeding
;
Portsite metastases
;
Implantation
;
Abdominal-wall metastases
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Medizin
Notizen:
Abstract Background: In order to test the influence of a pneumoperitoneum on the peritoneal implantation of free intraperitoneal colon cancer cells, 40 male syngeneic WAG rats were at random divided into four groups. Methods: Group 1 (n=10) animals underwent a midline laparotomy and 104 CC531 colon cancer cells were injected intraperitoneally (IP); in group 2 (n=10) 104 CC531 cells were injected IP without further manipulation; in group 3 (n=10) a pneumoperitoneum up to 10 mmHg was created after the IP injection of the same amount of CC531 cells. The pneumoperitoneum was maintained for 15 min. Finally in group 4 (n=10) after the IP injection of 104 CC531 cells and after the creation of a pneumoperitoneum, two 14-G IV catheters simulating trocars were introduced in each flank. A follow-up period of 8 weeks was used. Tumor implantation was scored according to the peritoneal cancer index of Eggermont and the index of Chauffert. Results: Tumor nodules were found varying from 60% in groups 1–3 to 50% in group 4. There was no statistical difference between the implantation rate in the four groups. A port-site recurrence was seen in group 4; all the other tumor implants were located in the mesenterium, omentum, internal genitals, or parietal peritoneum. Conclusions: The presence of a pneumoperitoneum does not enhance the implantation of free intraperitoneal malignant colon cancer cells in the rat, but the presence of a “port” may lead to abdominal-wall metastases.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF00189539
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