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  • 1
    Electronic Resource
    Electronic Resource
    Reexamination of granulovacuolar degeneration (1991)
    Springer
    Acta neuropathologica 82 (1991), S. 340-345 
    Details
    ISSN: 1432-0533
    Keywords: Ubiquitin ; granulovacuolar degeneration ; ageing
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Granulovacuolar degeneration (GVD) in the hippocampal pyramidal neurons of Alzheimer-type dementia was examined. Immunohistochemical examinations showed that the majority of centrally located granules were positive for ubiquitin. Based on electron microscopic observations, morphogenesis of GVD is considered to be as follows. Slight-to-moderate amounts of electron-dense material appear in the cytoplasm at the early stage, and are then surrounded and demarcated by a two-layered membrane (probably from smooth endoplasmic reticulum). Following this some inner material is digested forming floccular and liquid-like materials, while undigested material remains as coarse electron-dense granules. Specifically, granulovacuoles are considered to be an age-related special type of autophagosome. Analytical electron microscopy disclosed that the granules in GVD contained some aluminum.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00296544
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Light and electron microscopic and immunohistochemical observations of the Onuf's nucleus of amyotrophic lateral sclerosis (1991)
    Springer
    Acta neuropathologica 81 (1991), S. 610-614 
    Details
    ISSN: 1432-0533
    Keywords: Amyotrophic lateral sclerosis ; Bunina body ; Onuf's nucleus ; Ubiquitin ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We examined the Onufrowicz nucleus (Onuf's nucleus) of ten sporadic amyotrophic lateral sclerosis (ALS) patients with light and electron microscopic and immunohistochemical methods. Neurons in the Onuf's nucleus of ALS patients were better preserved than those in anterior horn cells. However, some showed morphological changes in the nucleus, namely, central chromatolytic changes, Bunina bodies, ubiquitin-positive filaments and spheroids. The Onuf's neurons of ALS patients showed more argentophilia than those of non-ALS patients. Electron microscopic observations revealed that neurofilaments were relatively more numerous in the Onuf's neurons of ALS patients. Bunina bodies and degenerated neurites were also seen in the Onuf's nucleus. In conclusion, the Onuf's nucleus in sporadic ALS patients showed some morphological changes similar to those noted in anterior horn cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00296370
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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