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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 151 (1992), S. 218-220 
    ISSN: 1432-1076
    Keywords: Vitamin B12 ; Methylmalonic aciduria ; Newborn screening ; Cobalamin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We describe two asymptomatic newborns with nutritional vitamin B12 deficiency in whom increased urinary methylmalonic acid was detected by routine neonatal screening at 3 weeks of age. Both infants were exclusively breast-fed. One mother suffered from pernicious anaemia, and the other was a strict vegetarian. Both mothers had no clinical or haematological abnormality, aside from a borderline mean corpuscular volume for the vegetarian mother. This report illustrates the early appearance of functional vitamin B12 deficiency in breastfed infants of vitamin B12-depleted mothers. It also demonstrates that urinary methylmalonic acid measurement is a sensitive indicator of tissue vitamin B12 deficiency.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1433-0407
    Keywords: Schlüsselwörter Schizophrenie ; Typische Antipsychotika ; Atypische Antipsychotika ; Umstellung ; Keywords Schizophrenia ; Conventional antipsychotics ; Atypical antipsychotics ; Conversion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract The introduction of atypical antipsychotics has presented new options for the pharmacological treatment of schizophrenic patients. It is assumed that in the near future, neuroleptic medication will shift from conventional to atypical antipsychotics for an increasing number of patients. The present article addresses guidelines for the conversion from conventional to atypical neuroleptics in inpatient and outpatient settings.
    Notes: Zusammenfassung Mit der Einführung der atypischen Antipsychotika haben sich neue Möglichkeiten in der pharmakotherapeutischen Behandlung schizophrener Patienten ergeben. Es ist anzunehmen, dass in den folgenden Jahren viele weitere Patienten von typischen auf atypische Präparate umgestellt werden. Der vorliegende Artikel befasst sich mit stationären und ambulanten Richtlinien zur Umstellung von typischen Neuroleptika auf atypische Antipsychotika. Diskutiert werden Möglichkeiten der Identifizierung geeigneter Kandidaten, Empfehlungen bei der Auswahl des atypischen Antipsychotikums und praktische Vorgehensweisen bei der Umstellung. Ergänzend werden Dosierungsrichtlinien der einzelnen atypischen Antipsychotika, mögliche Entzugssyndrome und andere Komplikationen des Präparatewechsels sowie substanzspezifische Aspekte der Umstellung dargestellt. Ein letztes Kapitel befasst sich mit den notwendigen psychotherapeutischen Interventionen, die im Rahmen einer Umstellung der antipsychotischen Medikation beachtet werden sollten.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-198X
    Keywords: Key words Uremia ; Homocysteine ; Cerebrovascular disease ; Thermolabile methylenetetrahydrofolate reductase variant ; Cystinosis ; Folic acid ; Vitamin B12
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  We report a 13-year-old girl with nephropathic cystinosis on chronic peritoneal dialysis who presented with two episodes of stroke. Laboratory evaluation showed severe hyperhomocysteinemia (108 µmol/l). Further testing revealed that she was homozygous for the thermolabile variant of the methylenetetrahydrofolate reductase (MTHFR) gene. Treatment with folic acid and vitamin B12 lowered plasma homocysteine to less than 20 µmol/l. No further episodes of stroke occurred over a follow-up of 12 months. Homocysteine levels should be measured in patients with chronic renal failure, since simple and safe treatment with folic acid and vitamin B12 is effective in lowering the plasma homocysteine level in patients with the thermolabile MTHFR allele.
    Type of Medium: Electronic Resource
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