Digitale Medien
Springer
Acta neuropathologica
75 (1987), S. 77-84
ISSN:
1432-0533
Schlagwort(e):
Wallerian degeneration
;
Myelin phagocytosis
;
Macrophages
;
Millipore diffusion chambers
;
Immunocytochemistry
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Medizin
Notizen:
Summary Myelin phagocytosis in Wallerian degeneration was studied using a model of murine sciatic nerve degeneration in millipore diffusion chambers in the peritoneal cavity of host mice. Immunocytological investigations showed the dependence of myelin digestion on the invasion of Fc-positive, Mac-1-positive and partly Ia-positive monocytes. Lymphocytes did not play a prominent role. Compared to Wallerian degeneration in situ, phagocytosis was decreased in nerves enclosed by millipore membranes on both sides of the chamber. The membrane acted as a trap for invading monocytes/macrophages. Neither tissue integrity nor genetic strain influenced the degree of phagocytosis. A modification of the experimental technique is introduced which permits myelin phagocytosis in the peritoneal cavity in a degree comparable to that in Wallerian degeneration in situ.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF00686796
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