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  • 1
    Electronic Resource
    Electronic Resource
    Myelin phagocytosis in Wallerian degeneration (1987)
    Springer
    Acta neuropathologica 75 (1987), S. 77-84 
    Details
    ISSN: 1432-0533
    Keywords: Wallerian degeneration ; Myelin phagocytosis ; Macrophages ; Millipore diffusion chambers ; Immunocytochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Myelin phagocytosis in Wallerian degeneration was studied using a model of murine sciatic nerve degeneration in millipore diffusion chambers in the peritoneal cavity of host mice. Immunocytological investigations showed the dependence of myelin digestion on the invasion of Fc-positive, Mac-1-positive and partly Ia-positive monocytes. Lymphocytes did not play a prominent role. Compared to Wallerian degeneration in situ, phagocytosis was decreased in nerves enclosed by millipore membranes on both sides of the chamber. The membrane acted as a trap for invading monocytes/macrophages. Neither tissue integrity nor genetic strain influenced the degree of phagocytosis. A modification of the experimental technique is introduced which permits myelin phagocytosis in the peritoneal cavity in a degree comparable to that in Wallerian degeneration in situ.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00686796
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Mechanisms of macrophage recruitment in Wallerian degeneration (1995)
    Springer
    Acta neuropathologica 89 (1995), S. 363-367 
    Details
    ISSN: 1432-0533
    Keywords: Key words C57BL/Ola mice ; Macrophage recruitment ; Myelin removal ; Wallerian degeneration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Monocytes/macrophages are important effector cells in myelin removal during Wallerian degeneration. Experiments with the mouse mutant C57BL/Ola revealed prolonged axonal survival and reduced phagocytic cell recruitment after nerve transsection. In the present study, we compared the course of Wallerian degeneration in peripheral nerves of C57BL and C57BL/Ola mice in vivo and in vitro. In vivo experiments confirmed earlier investigations describing a delayed d egeneration in the C57BL/Ola mutant compared with C57BL mice which were used as control animals without abnormal degeneration. Quite different results were seen in experiments in vitro: degenerating nerve segments of C57BL/Ola mice revealed pronounced axonal breakdown even in the absence of non-resident phagocytic cells. There was no difference in vitro compared with degenerating nerves from C57BL mice. The differences observed between the in vivo and in vitro situations suggest that axonal breakdown plays an important role in the initiation of macrophage recruitment to degenerating peripheral nerves.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00309630
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Mechanisms of macrophage recruitment in Wallerian degeneration (1995)
    Springer
    Acta neuropathologica 89 (1995), S. 363-367 
    Details
    ISSN: 1432-0533
    Keywords: C57BL/Ola mice ; Macrophage recruitment ; Myelin removal ; Wallerian degeneration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Monocytes/macrophages are important effector cells in myelin removal during Wallerian degeneration. Experiments with the mouse mutant C57BL/Ola revealed prolonged axonal survival and reduced phagocytic cell recruitment after nerve transsection. In the present study, we compared the course of Wallerian degeneration in peripheral nerves of C57BL and C57BL/Ola mice in vivo and in vitro. In vivo experiments confirmed earlier investigations describing a delayed degeneration in the C57BL/Ola mutant compared with C57BL mice which were used as control animals without abnormal degeneration. Quite different results were seen in experiments in vitro: degenerating nerve segments of C57BL/Ola mice revealed pronounced axonal breakdown even in the absence of non-resident phagocytic cells. There was no difference in vitro compared with degenerating nerves from C57BL mice. The differences observed between the in vivo and in vitro situations suggest that axonal breakdown plays an important role in the initiation of macrophage recruitment to degenerating peripheral nerves.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00309630
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    The angiogenesis of micrencephalic rat brains caused by methylazoxymethanol acetate (1985)
    Springer
    Acta neuropathologica 66 (1985), S. 253-263 
    Details
    ISSN: 1432-0533
    Keywords: Angiogenesis ; Micrencephaly ; MAMAc
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The angiogenesis of the rat cerebrum was studied under pathologic conditions caused by the administration of the neurotoxin methylazoxymethanol acetate (MAMAc) in the time (E14) of neuroblast migration. The sinovenous junction of the main superficial cerebral veins and the morphological changes of the veins were examined by a quantitative analytic method. The hypoplastic areas of the brains showed extremely malformed venous systems with pathologic changes of the sinovenous junctions depending on the degree of disturbance of the neuroblast migration. These findings suggest the primary role of the neuronal maturation in the angioarchitectonic development and the direct dependency of the vascular differentiation on the neuroblast migration of the drained territory.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00688591
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    The angiogenesis of micrencephalic rat brains caused by methylazoxymethanol acetate (1985)
    Springer
    Acta neuropathologica 68 (1985), S. 59-64 
    Details
    ISSN: 1432-0533
    Keywords: Angiogenesis ; Micrencephaly ; MAMAc
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The angioarchitecture of the superficial and basal arterial system of the hypoplastic rat brain caused by the administration of the neurotoxin, methylazoxymethanol acetate (MAMAc), at the time of neuroblast migration was studied. Increased variation of the arterial branching of the basal main stem of arteries and local vessel changes were observed. The findings suggest a close relationship between vascular and neuronal development, showing a generalized disturbance and local adaptation of vasculature to the altered neuronal architecture of the corresponding hypoplastic areas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00688957
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    Paper (German National Licenses)
    Fulltext
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