ISSN:
1432-0584
Keywords:
Lymphocytic leukemia
;
Immunoglobulin light chains
;
Western blotting
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The combination of two-dimensional mini gel electrophoresis with the ‘western blot’ technique proves to be a powerful tool in characterizing lymphoid cells. By testing for kappa and lambda immunoglobulin light chains we were able to differentiate between mono-, oligo-, and polyclonal B-cell diseases. The distribution of the lambda isotypes of 24 cases with chronic lymphocytic B-cell leukemia (B-CLL) tested was not random when compared to the distribution of the lambda light chains in B-lymphocytes of normal persons. This might implicate a genetic link between the lambda loci (chromosome 22) and the development of the lambda-CLL.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00320208
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