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  • 1
    Electronic Resource
    Electronic Resource
    Effect of lithium treatment on the GH-clonidine test in affective disorders (1988)
    Springer
    European journal of clinical pharmacology 35 (1988), S. 601-605 
    Details
    ISSN: 1432-1041
    Keywords: lithium ; clonidine ; GH response ; affective disorders ; α2-adrenoceptor regulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effects of short-term lithium (Li) administration on α2-adrenoceptor sensitivity was studied in 10 healthy volunteers and in 15 patients with normothymic, phasic depressive disorders. The GH-clonidine test was used to examine α2-adrenoceptor sensitivity, administered before and after Li treatment (600 mg/day for 7 days in controls and for 15 days in patients). Before treatment, the GH response to clonidine in the patients was blunted, and afterwards it tended to increase in the patients and it was significantly decreased in the controls. The difference between the response in the two groups was significant and was correlated both with the diagnosis and the pretreatment GH response to the stimulus. The opposing pattern of the response in patients and controls to Li administration suggests that the drug exerts a modulatory effect on α2-adrenoceptor sensitivity, with up or down regulation inversely correlated with pretreatment status.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00637595
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Plasma and intracellular kinetics of lithium after oral administration of various lithium salts (1977)
    Springer
    European journal of clinical pharmacology 12 (1977), S. 59-63 
    Details
    ISSN: 1432-1041
    Keywords: Lithium salts ; gastrointestinal absorption ; plasma and intracellular kinetics ; affective disorders
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Five healthy volunteers were treated orally with lithium carbonate, sulphate, or chloride. There were no significant differences in area under time-concentration curves, half-lives, total body clearance or apparent distribution volumes between the various salts, either in plasma or in the RBC compartment. The carbonate salt did show a higher RBC/plasma distribution ratio than the other salts, which might possibly imply greater therapeutic effectiveness of this salt. Some considerations on the tolerability of various lithium salts are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00561406
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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