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  • 1
    ISSN: 1432-1912
    Keywords: Microdialysis ; 5-HT release ; Chronic antidepressant ; Citalopram ; 5-HT reuptake inhibitor ; Tolerance ; Autoreceptors ; Frontal cortex Dorsal hippocampus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Rats were administered the selective serotonin (5-HT) uptake blocker citalopram or saline for 14 days to determine if prolonged treatment would lead to changes in extracellular 5-HT or autoreceptor sensitivity. One day after drug withdrawal, dialysis probes were implanted in the frontal cortex and dorsal hippocampus. Dialysis experiments were carried out using chloral hydrate anesthetized rats. The experimental protocol comprised the administration of three consecutive drug challenges: (1) After stable baseline levels were obtained, citalopram was infused through the dialysis probes to locally block uptake in the forebrain. (2) Subsequently, a 5-HT1B receptor agonist (RU24969 or CP93,129) was infused through the probe to test for changes in terminal autoreceptor sensitivity. (3) Last, citalopram was administered systemically to test the effect of indirect activation of somatodendritic autoreceptors. Under these conditions, with uptake already blocked locally in the forebrain, systemic citalopram produces a decrease in extracellular 5-HT, an effect that can be inhibited by pretreatment with antagonists of 5-HT1A receptors. The results indicate that during local infusion of citalopram extracellular 5-HT was significantly higher in the dorsal hippocampus of the chronic citalopram as compared to saline treatment group. This difference persisted throughout the full time course of the experiment. However, the decreases in 5-HT levels produced by local infusion of a 5-HT1B receptor agonist or after systemic citalopram administration were not significantly different between the chronic citalopram and saline treated groups. There were no significant differences between chronic citalopram and saline treated animals in frontal cortex. These results suggest that prolonged inhibition of 5-HT uptake may produce a selective change in the regulation of release from median raphe 5-HT neurons, but this change could not be clearly linked to a change in nerve terminal or somatodendritic autoreceptor sensitivity.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1912
    Keywords: Key words Microdialysis ; 5-HT release ; Chronic antidepressant ; Citalopram ; 5-HT reuptake inhibitor ; Tolerance ; Autoreceptors ; Frontal cortex ; Dorsal hippocampus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Rats were administered the selective serotonin (5-HT) uptake blocker citalopram or saline for 14 days to determine if prolonged treatment would lead to changes in extracellular 5-HT or autoreceptor sensitivity. One day after drug withdrawal, dialysis probes were implanted in the frontal cortex and dorsal hippocampus. Dialysis experiments were carried out using chloral hydrate anesthetized rats. The experimental protocol comprised the administration of three consecutive drug challenges: (1) After stable baseline levels were obtained, citalopram was infused through the dialysis probes to locally block uptake in the forebrain. (2) Subsequently, a 5-HT1B receptor agonist (RU24969 or CP93,129) was infused through the probe to test for changes in terminal autoreceptor sensitivity. (3) Last, citalopram was administered systemically to test the effect of indirect activation of somatodendritic autoreceptors. Under these conditions, with uptake already blocked locally in the forebrain, systemic citalopram produces a decrease in extracellular 5-HT, an effect that can be inhibited by pretreatment with antagonists of 5-HT1A receptors. The results indicate that during local infusion of citalopram extracellular 5-HT was significantly higher in the dorsal hippocampus of the chronic citalopram as compared to saline treatment group. This difference persisted throughout the full time course of the experiment. However, the decreases in 5-HT levels produced by local infusion of a 5-HT1B receptor agonist or after systemic citalopram administration were not significantly different between the chronic citalopram and saline treated groups. There were no significant differences between chronic citalopram and saline treated animals in frontal cortex. These results suggest that prolonged inhibition of 5-HT uptake may produce a selective change in the regulation of release from median raphe 5-HT neurons, but this change could not be clearly linked to a change in nerve terminal or somatodendritic autoreceptor sensitivity.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Mathematical geology 22 (1990), S. 723-742 
    ISSN: 1573-8868
    Keywords: constrained Delaunay triangulation ; interpolation ; approximation ; B-form representations associated with irregular triangles ; simplex splines
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Mathematics
    Notes: Abstract In the practice of administrative or engineering geosciences, the problem of deriving a digital surface representation from a map displaying contour lines of the interesting quantity is quite often encountered. First, alpha-numerical data are retrieved from the map by digitizing these contour lines pointwise into polygons. However, common “gridding” algorithms are known to fail at adequately reproducing the input contour lines due to the inhomogeneous and anisotropic areal distribution of the sites of the data sampled from given contour lines. Therefore, we suggest a new algorithm; the basic elements of its first stage are a constrained Delaunay triangulation of the data sites honoring their natural neighborhood relationship—i.e., whether they belong to the same contour line or not, and linear interpolation according to this triangulation of the data domain. In a second stage, a Bezier-Bernstein or simplex B-spline representation is easily achieved if a C1 or C2 smooth representation is required. At this stage, also, discontinuities of the function or its first directional derivatives with known locations in the data domain may be represented, provided this additional information has been taken into account when the triangulation was performed. The algorithm is numerically stable and efficient, and allows external interaction by the user to introduce his/her additional knowledge of the phenomenon to be studied, which may not be explicitly inherent in the available data.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Mathematical geology 22 (1990), S. 957-987 
    ISSN: 1573-8868
    Keywords: scattered data ; approximation ; simplicial B-splines ; constrained triangulation ; interactive geometric modeling
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Mathematics
    Notes: Abstract Bivariate quadratic simplicial B-splines are employed to obtain aC 1-smooth surface from scattered positional or directional geological data given over a two-dimensional domain. Vertices are generated according to the areal distribution of data sites, and polylines are defined along real geological features. The vertices and the polylines provide a constrained Delaunay triangulation of the domain. Note that the vertices do not generally coincide with the data sites. Six linearly independent simplex B-splines are associated with each triangle. Their defining knots and finite supports are automatically deduced from the vertices. Specific knot configurations result in discontinuities of the surface or its directional derivatives. Coefficients of a simplex spline representation are visualized as geometric points controlling the shape of the surface. This approach calls for geologic modeling and interaction of the geologist up front to define vertices and polylines, and to move control points initially given by an algorithm. Thus, simplex splines associated with irregular triangles seem to be well-suited to approximate and allow further geometrically modeling of geologic surfaces, including discontinuities, from scattered data. Applications to mathematical test as well as to real geological data are given as examples.
    Type of Medium: Electronic Resource
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