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  • 1
    Electronic Resource
    Electronic Resource
    Mechanisms of bombesin on growth of gastrinoma (PT)in vivo (1996)
    Springer
    Digestive diseases and sciences 41 (1996), S. 2180-2186 
    Details
    ISSN: 1573-2568
    Keywords: gastrinoma ; bombesin ; growth ; gastrin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The growth of the human gastrinoma model (PT) in athymic nude mice is stimulated by bombesin (BBS), an amphibian peptide homologous to both human gastrin-releasing peptide (GRP) and neuromedin B (NMB). The mechanism is not known, and a potent and specific GRP-R antagonist BIM26226, which has low affinity for NMB-R, was usedin vivo in athymic nude mice bearing gastrinoma subcutaneously. Both the BBS and BIM26226 stimulated the growth of PT, and the growth stimulation was even greater when given together. RT-PCR study of gastrinoma revealed the presence of both GRP-R and NMB-R mRNA, but much more abundant NMB-R mRNA. We conclude that BBS-stimulated growth of gastrinoma involves both GRP-R and NMB-R, and our findings suggest that GRP-R mediates negative and NMB-R produces positive growth effects on gastrinoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02071398
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Effects of aging on gastrin and somatostatin secretion from isolated perfused rat stomach (1993)
    Springer
    Digestive diseases and sciences 38 (1993), S. 303-308 
    Details
    ISSN: 1573-2568
    Keywords: bombesin ; carbachol ; peptone ; Fischer 344 rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We have examined the release of gastrin and somatostatin from the isolated perfused stomach of rats of three different age groups (4 months, 12 months, and 24 months old) in response to bombesin and carbachol. The basal release of gastrin was diminished in 24-month-old rats. Basal somatostatin release showed an age-related decrease. Bombesin (10−10 and 10−9 M) and carbachol (10−8 and 10−7 M) stimulated gastrin release in each age group. The integrated release of gastrin in response to bombesin (10−10 and 10−9 M) or carbachol (10−8 M) did not differ among the three age groups, although integrated gastrin release in response to carbachol (10−7 M) decreased in 24-month-old rats. Bombesin-stimulated release of somatostatin decreased in 12- and 24-month-old rats. Carbachol inhibited release of somatostatin in each age group. Compared with 4-month-old rats, the inhibition of somatostatin release by carbachol was less in 24-month-old rats at 10−8 and 10−7 M, and less in 12-month-old rats at 10−7 M. The decreased basal gastrin secretion and well-preserved gastrin response were further confirmed in conscious aged rats tested by means of oral gavage with 10% peptone. Our findings indicate that gastrin response to the stimuli is well preserved with aging, whereas the response of somatostatin diminishes in an age-related manner. Aging has different effects on the release of gastrin and somatostatin from the rat stomach.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01307548
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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